Results from the Loire-Ardèche-Drôme-Isère-Puy-de-Dôme (LADIP) trial on atrial flutter, a multicentric prospective randomized study comparing amiodarone and radiofrequency ablation after the first episode of symptomatic atrial flutter

There is no published randomized study comparing amiodarone therapy and radiofrequency catheter ablation (RFA) after only 1 episode of symptomatic atrial flutter (AFL). The aim of the Loire-Ardèche-Drôme-Isère-Puy-de-Dôme (LADIP) Trial of Atrial Flutter was 2-fold: (1) to prospectively compare first...

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Bibliographic Details
Published in:Circulation (New York, N.Y.) N.Y.), 2006-10, Vol.114 (16), p.1676-1681
Main Authors: DA COSTA, Antoine, THEVENIN, Jérome, PAGES, J. Marie, BONIJOLY, Serge, LAMAISON, Dominique, DEFAYE, Pascal, BARTHELEMY, J. Claude, GOUTTARD, Thierry, ISAAZ, Karl, ROCHE, Frédéric, ROMEYER-BOUCHARD, Cécile, ABDELLAOUI, Loucif, MESSIER, Marc, DENIS, Lucien, FAURE, Emmanuel, GONTHIER, Régis, KRUSZYNSKI, Georges
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Amiodarone - therapeutic use
Atrial Flutter - drug therapy
Atrial Flutter - epidemiology
Atrial Flutter - surgery
Biological and medical sciences
Blood and lymphatic vessels
Cardiology. Vascular system
Cardiovascular system
Catheter Ablation
Diseases of the cardiovascular system
Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous
Female
Follow-Up Studies
France
Humans
Male
Medical sciences
Pharmacology. Drug treatments
Prospective Studies
Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)
Treatment Outcome
Vasodilator agents. Cerebral vasodilators
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Summary:There is no published randomized study comparing amiodarone therapy and radiofrequency catheter ablation (RFA) after only 1 episode of symptomatic atrial flutter (AFL). The aim of the Loire-Ardèche-Drôme-Isère-Puy-de-Dôme (LADIP) Trial of Atrial Flutter was 2-fold: (1) to prospectively compare first-line RFA (group I) versus cardioversion and amiodarone therapy (group II) after only 1 AFL episode; and (2) to determine the impact of both treatments on the long-term risk of subsequent atrial fibrillation (AF). From October 2002 to February 2006, 104 patients (aged 78+/-5 years; 20 women) with AFL were included, with 52 patients in group I and 52 patients in group II. The cumulative risk of AFL or AF was interpreted with the use of Kaplan-Meier curves and compared by the log-rank test. Clinical presentation, echocardiographic data, and follow-up were as follows: age (78.5+/-5 versus 78+/-5 years), history of AF (27% versus 21.6%); structural heart disease (58% versus 65%), left ventricular ejection fraction (56+/-14% versus 54.5+/-14%), left atrial size (43+/-7 versus 43+/-6 mm), mean follow-up (13+/-6 versus 13+/-6 months; P=NS), recurrence of AFL (3.8% versus 29.5%; P
ISSN:0009-7322
1524-4539
DOI:10.1161/CIRCULATIONAHA.106.638395