Quantitative perihematomal blood flow in spontaneous intracerebral hemorrhage predicts in-hospital functional outcome

Few data on xenon computed tomography-based quantitative cerebral blood flow (CBF) in spontaneous intracerebral hemorrhage have been reported. We correlated perihematomal CBF in a retrospective series of 42 subacute spontaneous intracerebral hemorrhage patients undergoing xenon computed tomography w...

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Bibliographic Details
Published in:Stroke (1970) 2007-02, Vol.38 (2), p.319-324
Main Authors: TAYAL, Ashis H, GUPTA, Rishi, YONAS, Howard, JOVIN, Tudor, UCHINO, Ken, HAMMER, Maxim, WECHSLER, Lawrence, GEBEL, James M
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Biological and medical sciences
Blood Flow Velocity - physiology
Brain - blood supply
Brain - physiology
Cerebral Hemorrhage - epidemiology
Cerebral Hemorrhage - physiopathology
Cerebrovascular Circulation - physiology
Emergency and intensive cardiocirculatory care. Cardiogenic shock. Coronary intensive care
Hospitalization
Humans
Intensive care medicine
Investigative techniques, diagnostic techniques (general aspects)
Medical sciences
Middle Aged
Nervous system
Neurology
Predictive Value of Tests
Radionuclide investigations
Retrospective Studies
Treatment Outcome
Vascular diseases and vascular malformations of the nervous system
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Summary:Few data on xenon computed tomography-based quantitative cerebral blood flow (CBF) in spontaneous intracerebral hemorrhage have been reported. We correlated perihematomal CBF in a retrospective series of 42 subacute spontaneous intracerebral hemorrhage patients undergoing xenon computed tomography with in-hospital discharge status and mortality. We calculated 3 area-weighted mean CBF values: (1) within the computed tomography-visible rim of perihematomal edema, (2) within a 1-cm marginal radius around the hematoma, and (3) all cortical regions of interest immediately adjacent to the hematoma. Primary outcomes were in-hospital mortality and discharge status (ordinally as 0=home, 1=acute rehabilitation, 2=nursing home, 3=death). Discharge status was used as a surrogate for in-hospital functional outcome. Median hematoma volume was 14.4 cm(3) (range, 2 to 70). Median perihematomal (low-attenuation rim) CBF was 21.9 cm(3).100 g(-1).min(-1) (range, 6.1 to 81.1), and the median 1-cm marginal radius CBF was 26.8 cm(3).100 g(-1).min(-1) (range, 10.8 to 72.8). The median regional cortical CBF was 26.7 cm(3).100 g(-1).min(-1) (range, 6.9 to 72.6). Eight patients had 1-cm marginal radius or regional cortical CBF values
ISSN:0039-2499
1524-4628
DOI:10.1161/01.STR.0000254492.35504.db