Effect of Beta-Blockade on Ascending Aortic Dilatation in Children With the Marfan Syndrome

Aortic root dilatation is the principal life-threatening complication in Marfan syndrome, leading to aortic regurgitation, dissection, and rupture. Beta blockade slows aortic dilatation in adults, but there has been no definitive evidence in children. Therefore, the evolution of aortic diameter at t...

Full description

Saved in:
Bibliographic Details
Published in:The American journal of cardiology 2007-02, Vol.99 (3), p.406-409
Main Authors: Ladouceur, Magalie, MD, Fermanian, Christophe, PhD, Lupoglazoff, Jean-Marc, MD, Edouard, Thomas, MD, Dulac, Yves, MD, Acar, Philippe, MD, Magnier, Suzel, MD, Jondeau, Guillaume, MD, PhD
Format: Article
Language:English
Subjects:
Adrenergic beta-Antagonists - therapeutic use
Aortic Diseases - drug therapy
Aortic Diseases - etiology
Biological and medical sciences
Cardiology
Cardiology. Vascular system
Cardiovascular
Cardiovascular disease
Child
Children & youth
Dilatation, Pathologic - diagnostic imaging
Dilatation, Pathologic - drug therapy
Dilatation, Pathologic - etiology
Echocardiography
Female
Follow-Up Studies
Genetic disorders
Humans
Male
Marfan Syndrome - complications
Medical sciences
Pediatrics
Retrospective Studies
Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis
Severity of Illness Index
Sinus of Valsalva
Treatment Outcome
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Aortic root dilatation is the principal life-threatening complication in Marfan syndrome, leading to aortic regurgitation, dissection, and rupture. Beta blockade slows aortic dilatation in adults, but there has been no definitive evidence in children. Therefore, the evolution of aortic diameter at the level of the sinuses of Valsalva in 155 children (82 males, 73 females) aged
ISSN:0002-9149
1879-1913
DOI:10.1016/j.amjcard.2006.08.048