Does intensity of rate-control influence outcome in atrial fibrillation? An analysis of pooled data from the RACE and AFFIRM studies

The AFFIRM and RACE studies showed that rate control is an acceptable treatment strategy for atrial fibrillation (AF). We examined whether strict rate control offers benefit over more lenient rate control. We compared the outcome of patients enrolled in the rate-control arms of AFFIRM and RACE, usin...

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Bibliographic Details
Published in:Europace (London, England) England), 2006-11, Vol.8 (11), p.935-942
Main Authors: Van Gelder, Isabelle C, Wyse, D George, Chandler, Mary L, Cooper, Howard A, Olshansky, Brian, Hagens, Vincent E, Crijns, Harry J G M
Format: Article
Language:English
Subjects:
Aged
Atrial Fibrillation - diagnosis
Atrial Fibrillation - mortality
Atrial Fibrillation - therapy
Cardiac Pacing, Artificial - methods
Cardiac Pacing, Artificial - mortality
Clinical Trials as Topic - statistics & numerical data
Female
Heart Rate
Humans
International Cooperation
Male
Middle Aged
Outcome Assessment (Health Care) - methods
Outcome Assessment (Health Care) - statistics & numerical data
Prognosis
Proportional Hazards Models
Retrospective Studies
Risk Assessment - methods
Risk Factors
Survival Analysis
Survival Rate
Treatment Outcome
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Summary:The AFFIRM and RACE studies showed that rate control is an acceptable treatment strategy for atrial fibrillation (AF). We examined whether strict rate control offers benefit over more lenient rate control. We compared the outcome of patients enrolled in the rate-control arms of AFFIRM and RACE, using data from patients who met a composite of overlapping inclusion and exclusion criteria. We evaluated 1091 patients, 874 from AFFIRM and 217 from RACE. In AFFIRM, the rate-control strategy aimed for a resting heart rate < or =80 bpm and heart rate during daily activity of < or =110 bpm. In RACE, a more lenient approach was taken: resting heart rate
ISSN:1099-5129
1532-2092
DOI:10.1093/europace/eul106