Data acquisition for the histoculture drug response assay in lung cancer

Objective Application of the histoculture drug response assay for lung cancer was investigated by using data acquired from lung cancer specimens. Methods From May 1994 through February 2005, histoculture drug response assay data were obtained from 359 lung cancer specimens held in our institute. We...

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Published in:The Journal of thoracic and cardiovascular surgery 2007-02, Vol.133 (2), p.303-308
Main Authors: Yoshimasu, Tatsuya, MD, PhD, Oura, Shoji, MD, PhD, Hirai, Issei, MD, PhD, Tamaki, Takeshi, MD, Kokawa, Yozo, MD, PhD, Hata, Kazuhito, MD, Ohta, Fuminori, MD, Nakamura, Rie, MD, Kawago, Mitsumasa, MD, Tanino, Hirokazu, MD, PhD, Okamura, Yoshitaka, MD, PhD, Furukawa, Tomoko, MD, PhD
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Analysis of Variance
Antineoplastic Combined Chemotherapy Protocols - pharmacology
Biological and medical sciences
Biopsy, Needle
Cardiothoracic Surgery
Cisplatin - pharmacology
Deoxycytidine - analogs & derivatives
Deoxycytidine - pharmacology
Dose-Response Relationship, Drug
Doxorubicin - pharmacology
Drug Resistance, Neoplasm
Drug Screening Assays, Antitumor
Etoposide - pharmacology
Female
Fluorouracil - pharmacology
Humans
Lung Neoplasms - drug therapy
Lung Neoplasms - pathology
Male
Medical sciences
Middle Aged
Paclitaxel - pharmacology
Pneumology
Probability
Retrospective Studies
Sensitivity and Specificity
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Surgery of the heart
Tumor Cells, Cultured
Tumors of the respiratory system and mediastinum
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Summary:Objective Application of the histoculture drug response assay for lung cancer was investigated by using data acquired from lung cancer specimens. Methods From May 1994 through February 2005, histoculture drug response assay data were obtained from 359 lung cancer specimens held in our institute. We examined chemosensitivities of the tissues to cisplatin, doxorubicin, mitomycin C, 5-fluorouracil, docetaxel, paclitaxel, etoposide, irinotecan, and gemcitabine. Cutoff inhibition rates were determined with each drug for non–small cell lung cancer and were used to calculate predictabilities for chemotherapy responses. Results The evaluability of the histoculture drug response assay was high at 97.4%. Good predictability, including true-positive and true-negative rates of 73.2% and 100%, respectively, with an accuracy of 83.0%, was observed. Conclusion The histoculture drug response assay appears to be applicable to non–small cell lung cancer for the prediction of responses to chemotherapy.
ISSN:0022-5223
1097-685X
DOI:10.1016/j.jtcvs.2006.06.030