Metabolic syndrome and risk of incident cardiovascular events and death : A systematic review and meta-analysis of longitudinal studies

The purpose of this research was to assess the association between the metabolic syndrome (MetSyn) and cardiovascular events and mortality by meta-analyses of longitudinal studies. Controversy exists regarding the cardiovascular risk associated with MetSyn. We searched electronic reference databases...

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Bibliographic Details
Published in:Journal of the American College of Cardiology 2007-01, Vol.49 (4), p.403-414
Main Authors: GAMI, Apoor S, WITT, Brandi J, HOWARD, Daniel E, ERWIN, Patricia J, GAMI, Lisa A, SOMERS, Virend K, MONTORI, Victor M
Format: Article
Language:English
Subjects:
Atherosclerosis (general aspects, experimental research)
Bias
Biological and medical sciences
Blood and lymphatic vessels
Cardiology
Cardiology. Vascular system
Cardiovascular disease
Cardiovascular Diseases - etiology
Cardiovascular Diseases - mortality
Cholesterol
Health risk assessment
Humans
Longitudinal Studies
Medical sciences
Metabolic diseases
Metabolic syndrome
Metabolic Syndrome - complications
Miscellaneous
Older people
Other metabolic disorders
Risk Factors
Studies
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Summary:The purpose of this research was to assess the association between the metabolic syndrome (MetSyn) and cardiovascular events and mortality by meta-analyses of longitudinal studies. Controversy exists regarding the cardiovascular risk associated with MetSyn. We searched electronic reference databases through March 2005, studies that referenced Reaven's seminal article, abstracts presented at meetings in 2003 to 2004, and queried experts. Two reviewers independently assessed eligibility. Longitudinal studies reporting associations between MetSyn and cardiovascular events or mortality were eligible. Two reviewers independently used a standardized form to collect data from published reports. Authors were contacted. Study quality was assessed by the control of selection, detection, and attrition biases. We found 37 eligible studies that included 43 cohorts (inception 1971 to 1997) and 172,573 individuals. Random effects meta-analyses showed MetSyn had a relative risk (RR) of cardiovascular events and death of 1.78 (95% confidence interval [CI] 1.58 to 2.00). The association was stronger in women (RR 2.63 vs. 1.98, p = 0.09), in studies enrolling lower risk (
ISSN:0735-1097
1558-3597
DOI:10.1016/j.jacc.2006.09.032