Calcium, dietary, and lifestyle factors in the prevention of colorectal adenomas

BACKGROUND. Many studies have suggested a role for calcium in reducing the risk of colorectal adenomas and cancer but its effectiveness may be dependent on interactions with other dietary and/or lifestyle factors. We examined the association between calcium and prevalence of adenomas and assessed wh...

Full description

Saved in:
Bibliographic Details
Published in:Cancer 2007-02, Vol.109 (3), p.510-517
Main Authors: Miller, Eric A., Keku, Temitope O., Satia, Jessie A., Martin, Christopher F., Galanko, Joseph A., Sandler, Robert S.
Format: Article
Language:English
Subjects:
adenoma
Adenoma - prevention & control
Adenomatous Polyps
Anti-Inflammatory Agents, Non-Steroidal - administration & dosage
Biological and medical sciences
calcium
Calcium - administration & dosage
colorectal neoplasms
Colorectal Neoplasms - prevention & control
Cross-Sectional Studies
Diet
Dietary Fats - administration & dosage
fats
Female
Gastroenterology. Liver. Pancreas. Abdomen
Humans
Life Style
Male
Medical sciences
Middle Aged
NSAID
Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
Tumors
Vitamin D - analogs & derivatives
Vitamin D - blood
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:BACKGROUND. Many studies have suggested a role for calcium in reducing the risk of colorectal adenomas and cancer but its effectiveness may be dependent on interactions with other dietary and/or lifestyle factors. We examined the association between calcium and prevalence of adenomas and assessed whether the association was stronger in biologically plausible subgroups. METHODS. Cross‐sectional data from 222 cases and 479 adenoma‐free controls who underwent colonoscopies and completed food frequency and lifestyle questionnaires were used in the analyses. Multivariable logistic regression was used to estimate the association between calcium and prevalence of adenomas. Stratified analyses and the likelihood ratio test were used to examine effect modification by various demographic, lifestyle, and behavioral factors. RESULTS. Overall, little association was observed comparing total calcium intake of ≥900 mg/day to
ISSN:0008-543X
1097-0142
DOI:10.1002/cncr.22453