Improved test-retest reliability of 50-ms paired-click auditory gating using magnetoencephalography source modeling

Used to study filtering abnormalities in schizophrenia, the paired‐click paradigm suffers from poor test–retest reliability of the gating ratio, calculated from the P50 component of the ERP recorded at Cz approximately 50 ms following each of two stimuli. This study sought to improve reliability by...

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Bibliographic Details
Published in:Psychophysiology 2007-01, Vol.44 (1), p.86-90
Main Authors: Lu, Brett Y., Edgar, J. Christopher, Jones, Aaron P., Smith, Ashley K., Huang, Ming-Xiong, Miller, Gregory A., Cañive, Jose M.
Format: Article
Language:English
Subjects:
Acoustic Stimulation
Adult
Auditory gating
Auditory Perception - physiology
Electroencephalography
Evoked Potentials, Auditory - physiology
Female
Humans
Magnetoencephalography
Male
Middle Aged
Models, Psychological
Psychometrics
Reliability
Reproducibility of Results
Source modeling
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Summary:Used to study filtering abnormalities in schizophrenia, the paired‐click paradigm suffers from poor test–retest reliability of the gating ratio, calculated from the P50 component of the ERP recorded at Cz approximately 50 ms following each of two stimuli. This study sought to improve reliability by assessing 50‐ms gating at primary auditory cortices (PAC), the main generators of the P50 Cz component. MEG source modeling was used, taking advantage of the tangentially oriented PAC sources. Ten healthy subjects underwent three sessions, during which Cz‐based and PAC‐derived gating was measured. Unlike Cz P50, gating ratios at bilateral PACs achieved an intraclass coefficient of .8 or greater. Variability of gating within the same subject was also significantly smaller for bilateral PACs than for Cz P50. Paired‐click gating ratio reliability can be improved by examining the individual PACs rather than composite scalp‐recorded activity.
ISSN:0048-5772
1540-5958
1469-8986
DOI:10.1111/j.1469-8986.2006.00478.x