Breast cancer markers

This review illustrates the relationships linking the ER and the ErbB family of receptor tyrosine kinases and their kinase pathways in breast cancer. The central role of the ER in activating tumour growth linked gene transcription as well as the cooperating nuclear co-factors very likely implicated...

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Bibliographic Details
Published in:	Cancer letters 2006-11, Vol.243 (2), p.145-159
Main Author:	Giancotti, Vincenzo
Format:	Article
Language:	eng
Subjects:	Biomarkers, Tumor - metabolism BRCA1 Protein - metabolism Breast cancer Breast Neoplasms - metabolism Breast Neoplasms - pathology Cadherins - metabolism Cancer therapies Epidermal growth factor Epigenetics Estrogens Female Gene expression Humans Kinases Markers Medical prognosis Models, Biological Phosphorylation Proteins Proto-Oncogene Proteins c-akt - metabolism Receptors, Estrogen - metabolism Studies Transcription Factor AP-1 - metabolism Tumors
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Summary:	This review illustrates the relationships linking the ER and the ErbB family of receptor tyrosine kinases and their kinase pathways in breast cancer. The central role of the ER in activating tumour growth linked gene transcription as well as the cooperating nuclear co-factors very likely implicated in breast cancer tumourigenesis is discussed. The action of ErbB family members has been located upstream of the kinase pathways that begin at plasma membrane and end at the nucleus after complex interconnections with many factors, such as AP-1. The important role of MAPKs and PKB/Akt in cell survival and tumour proliferation is highlighted. Also other factors are discussed such as Fra-1 (a member of the AP-1 complex), E-cadherin (a tumour suppressor), and BRCA1 (another factor involved in tumour growth inhibition). Lactoferrin protein (characteristic of healthy tissues) and resistance proteins have also been briefly discussed.
ISSN:	0304-3835 1872-7980