Improvement of the synthetic tri-peptide vaccine (S3Pvac) against porcine Taenia solium cysticercosis in search of a more effective, inexpensive and manageable vaccine

Abstract Vaccination of pigs may curtail Taenia solium transmission by reducing the number of cysticerci, the precursors of adult intestinal tapeworms in humans. Several antigen preparations induce protection against porcine cysticercosis in experimental settings but only one subunit vaccine (S3Pvac...

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Bibliographic Details
Published in:Vaccine 2007-02, Vol.25 (8), p.1368-1378
Main Authors: Sciutto, Edda, Rosas, Gabriela, Hernández, Marisela, Morales, Julio, Cruz-Revilla, Carmen, Toledo, Andrea, Manoutcharian, Karen, Gevorkian, Goar, Blancas, Abel, Acero, Gonzalo, Hernández, Beatriz, Cervantes, Jacquelynne, Bobes, Raul J, Goldbaum, Fernando A, Huerta, Mirna, Diaz-Orea, Alicia, Fleury, Agnes, de Aluja, Aline S, Cabrera-Ponce, Jose Luis, Herrera-Estrella, Luis, Fragoso, Gladis, Larralde, Carlos
Format: Article
Language:English
Subjects:
Allergy and Immunology
Animals
Applied microbiology
Biological and medical sciences
Control
Cysticercosis
Cysticercosis - parasitology
Cysticercosis - prevention & control
Cysticercosis - transmission
Cysticercosis - veterinary
Diseases caused by cestodes
Fundamental and applied biological sciences. Psychology
Helminthic diseases
Infectious diseases
Medical sciences
Microbiology
Parasitic diseases
S3Pvac improvement
Swine
Swine Diseases - immunology
Swine Diseases - parasitology
Swine Diseases - prevention & control
Swine Diseases - transmission
Taenia solium
Taenia solium - immunology
Vaccination
Vaccination - economics
Vaccination - methods
Vaccination - veterinary
Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)
Vaccines, Subunit - economics
Vaccines, Subunit - immunology
Vaccines, Subunit - therapeutic use
Vaccines, Synthetic - economics
Vaccines, Synthetic - immunology
Vaccines, Synthetic - therapeutic use
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Summary:Abstract Vaccination of pigs may curtail Taenia solium transmission by reducing the number of cysticerci, the precursors of adult intestinal tapeworms in humans. Several antigen preparations induce protection against porcine cysticercosis in experimental settings but only one subunit vaccine (S3Pvac) has been tested and proved effective in the field against naturally acquired disease. Besides improving of the vaccine's effectiveness, significant reductions in production costs and in the logistics of its administration are necessary for the feasibility of nationwide control programs. This review highlights the development of several versions of S3Pvac aimed to increase effectiveness, reduce costs and increase feasibility by novel delivery systems and alternative routes of administration.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2006.10.018