Persistent B‐cell Lymphopenia, Multiorgan Disease, and Erythema Multiforme Caused by Mycoplasma pneumoniae Infection

:  We report a 6‐year‐old girl in whom Mycoplasma pneumoniae infection presenting with erythema multiforme, multiorgan, and hematologic dysfunctions induced a long‐standing, marked B‐cell lymphopenia. An increase of CD8+ lymphocytes was also detected. We suggest that a selective cytotoxic T lymphocy...

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Bibliographic Details
Published in:Pediatric dermatology 2005-11, Vol.22 (6), p.558-560
Main Authors: Martire, Baldassarre, Foti, Caterina, Cassano, Nicoletta, Buquicchio, Rosalba, Vecchio, Giovanni Carlo, Mattia, Domenico
Format: Article
Language:English
Subjects:
Acetaminophen - therapeutic use
Anti-Bacterial Agents - therapeutic use
B-Lymphocytes - immunology
Bacteremia - complications
Bacteremia - diagnosis
Bacteremia - drug therapy
Biological and medical sciences
Bullous diseases of the skin
Child
Clarithromycin - therapeutic use
Dermatology
Drug Therapy, Combination
Erythema Multiforme - etiology
Erythema Multiforme - physiopathology
Erythema Multiforme - therapy
Female
Follow-Up Studies
Hematologic and hematopoietic diseases
Humans
Lymphopenia - drug therapy
Lymphopenia - etiology
Lymphopenia - physiopathology
Medical sciences
Multiple Organ Failure - etiology
Multiple Organ Failure - physiopathology
Multiple Organ Failure - therapy
Mycoplasma Infections - complications
Mycoplasma Infections - diagnosis
Mycoplasma Infections - drug therapy
Mycoplasma pneumoniae
Mycoplasma pneumoniae - isolation & purification
Other diseases. Hematologic involvement in other diseases
Prednisone - therapeutic use
Risk Assessment
Treatment Outcome
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Summary::  We report a 6‐year‐old girl in whom Mycoplasma pneumoniae infection presenting with erythema multiforme, multiorgan, and hematologic dysfunctions induced a long‐standing, marked B‐cell lymphopenia. An increase of CD8+ lymphocytes was also detected. We suggest that a selective cytotoxic T lymphocyte‐dependent B cell lysis and the expansion of super‐antigen activated CD8+ T cells may account for the multiorgan and hematologic disturbances triggered by M. pneumoniae.
ISSN:0736-8046
1525-1470
DOI:10.1111/j.1525-1470.2005.00140.x