Alterations in cell-mediated immune response in subacute sclerosing panencephalitis

To investigate T cell responses in subacute sclerosing panencephalitis (SSPE), we analyzed proliferation and cytokine secretion of cells from 35 patients and 42 healthy controls (HC) in response to central nervous system (CNS) antigens. The proliferation in response to myelin basic protein (MBP), my...

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Bibliographic Details
Published in:Journal of neuroimmunology 2005-12, Vol.170 (1), p.179-185
Main Authors: Yentür, Sibel P., Gürses, Candan, Demirbilek, Veysi, Yılmaz, Gülden, Önal, Ayşe Emel, Yapıcı, Zuhal, Yalçınkaya, Cengiz, Çokar, Özlem, Gökyiğit, Ayşen, Saruhan-Direskeneli, Güher
Format: Article
Language:English
Subjects:
Adolescent
Adult
alpha-Crystallin B Chain
Case-Control Studies
Cell Proliferation
Child
Child, Preschool
Cytokines - biosynthesis
Humans
IL-121
Immunity, Cellular
Infant
Intermediate Filament Proteins - immunology
MBP
Measles virus
MOG
Monocytes - metabolism
Monocytes - pathology
Myelin Basic Protein - immunology
Myelin Proteins
Myelin-Associated Glycoprotein - immunology
Myelin-Oligodendrocyte Glycoprotein
Nerve Tissue Proteins - immunology
Protein Kinases - immunology
Recombinant Proteins - immunology
Subacute sclerosing panencephalitis (SSPE)
Subacute Sclerosing Panencephalitis - blood
Subacute Sclerosing Panencephalitis - immunology
Subacute Sclerosing Panencephalitis - pathology
αB-crystallin
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Summary:To investigate T cell responses in subacute sclerosing panencephalitis (SSPE), we analyzed proliferation and cytokine secretion of cells from 35 patients and 42 healthy controls (HC) in response to central nervous system (CNS) antigens. The proliferation in response to myelin basic protein (MBP), myelin oligodendrocyte-glycoprotein (MOG) and αB-crystallin did not differ between groups. There was a trend towards a decrease in IL-12 production in response to MBP and in vitro IL-12 secretion of SSPE patients to measles virus vaccine (MVV) was lower than controls. Proliferation, as well as IFN-γ, IL-12 and IL-10 production in response to purified protein derivate (PPD) was impaired in SSPE patients. The results did not demonstrate any by-stander cellular response against myelin antigens, implicating that CNS is not a predominant target of an autoimmune response in SSPE. The recall responses were lower in SSPE as reported in measles before.
ISSN:0165-5728
1872-8421
DOI:10.1016/j.jneuroim.2005.09.002