PirB Restricts Ocular-Dominance Plasticity in Visual Cortex

Experience can alter synaptic connectivity throughout life, but the degree of plasticity present at each age is regulated by mechanisms that remain largely unknown. Here, we demonstrate that Paired-immunoglobulin-like receptor B (PirB), a major histocompatibility complex class I (MHCI) receptor, is...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 2006-09, Vol.313 (5794), p.1795-1800
Main Authors: Syken, Josh, GrandPre, Tadzia, Kanold, Patrick O, Shatz, Carla J
Format: Article
Language:English
Subjects:
Aging
Animals
Biological and medical sciences
Brain
Brain - metabolism
Cells, Cultured
Critical periods
Cytoskeletal Proteins - genetics
Cytoskeletal Proteins - metabolism
Dominance, Ocular - physiology
Eye and associated structures. Visual pathways and centers. Vision
Eyes
Eyes & eyesight
Fundamental and applied biological sciences. Psychology
Histocompatibility Antigens Class I - metabolism
Immune system
In Situ Hybridization
Intracellular Signaling Peptides and Proteins - metabolism
Messenger RNA
Mice
Mice, Inbred C57BL
Mutation
Nerve Tissue Proteins - genetics
Nerve Tissue Proteins - metabolism
Nervous system
Neuronal Plasticity
Neurons
Neurons - metabolism
Phosphorylation
Plasticity
Protein Binding
Protein Structure, Tertiary
Protein Tyrosine Phosphatase, Non-Receptor Type 11
Protein Tyrosine Phosphatase, Non-Receptor Type 6
Protein Tyrosine Phosphatases - metabolism
Proteins
Receptors
Receptors, Immunologic - chemistry
Receptors, Immunologic - genetics
Receptors, Immunologic - metabolism
Receptors, Immunologic - physiology
Recombinant Fusion Proteins - metabolism
Rodents
Synapses - metabolism
Synapses - physiology
Vertebrates: nervous system and sense organs
Visual cortex
Visual Cortex - physiology
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Summary:Experience can alter synaptic connectivity throughout life, but the degree of plasticity present at each age is regulated by mechanisms that remain largely unknown. Here, we demonstrate that Paired-immunoglobulin-like receptor B (PirB), a major histocompatibility complex class I (MHCI) receptor, is expressed in subsets of neurons throughout the brain. Neuronal PirB protein is associated with synapses and forms complexes with the phosphatases Shp-1 and Shp-2. Soluble PirB fusion protein binds to cortical neurons in an MHCI-dependent manner. In mutant mice lacking functional PirB, cortical ocular-dominance plasticity is more robust at all ages. Thus, an MHCI receptor is expressed in central nervous system neurons and functions to limit the extent of experience-dependent plasticity in the visual cortex throughout life. PirB is also expressed in many other regions of the central nervous system, suggesting that it may function broadly to stabilize neural circuits.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.1128232