Role of fibroblast growth factor-23 in peripheral vascular calcification in non-diabetic and diabetic hemodialysis patients

Fibroblast growth factor (FGF) 23 is a recently identified circulating factor that regulates phosphate (Pi) metabolism. Since the derangement of Pi control is an important risk factor for vascular calcification, we investigated the importance of plasma FGF-23 in the development of vascular calcifica...

Full description

Saved in:
Bibliographic Details
Published in:Osteoporosis international 2006-10, Vol.17 (10), p.1506-1513
Main Authors: INABA, M, OKUNO, S, IMANISHI, Y, YAMADA, S, SHIOI, A, YAMAKAWA, T, ISHIMURA, E, NISHIZAWA, Y
Format: Article
Language:English
Subjects:
Adult
Aged
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Aorta, Abdominal - diagnostic imaging
Aortic Valve Stenosis - blood
Aortic Valve Stenosis - diagnostic imaging
Aortic Valve Stenosis - etiology
Biological and medical sciences
Biomarkers - blood
Blood vessels
Calcinosis - blood
Calcinosis - diagnostic imaging
Calcinosis - etiology
Diabetes
Diabetes Mellitus, Type 2 - complications
Diabetes. Impaired glucose tolerance
Diabetic Angiopathies - blood
Diseases of the osteoarticular system
Emergency and intensive care: renal failure. Dialysis management
Endocrine pancreas. Apud cells (diseases)
Endocrinopathies
Etiopathogenesis. Screening. Investigations. Target tissue resistance
Fibroblast Growth Factors - blood
Fibroblast Growth Factors - physiology
Hand - blood supply
Hand - diagnostic imaging
Hemodialysis
Humans
Intensive care medicine
Male
Medical sciences
Metabolism
Middle Aged
Osteoporosis. Osteomalacia. Paget disease
Peripheral Vascular Diseases - blood
Peripheral Vascular Diseases - diagnostic imaging
Peripheral Vascular Diseases - etiology
Phosphates
Proteins
Radiography
Renal Dialysis - adverse effects
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Fibroblast growth factor (FGF) 23 is a recently identified circulating factor that regulates phosphate (Pi) metabolism. Since the derangement of Pi control is an important risk factor for vascular calcification, we investigated the importance of plasma FGF-23 in the development of vascular calcification in the aorta and peripheral artery in hemodialysis patients with and without diabetes mellitus (DM). Male hemodialysis patients with DM (n=32) and without DM (n=56) were examined. Plasma samples were obtained before the start of dialysis sessions, and the FGF-23 levels were determined by enzyme-linked immunosorbent assay. Roentgenography of the aorta and hand artery was performed, and visible vascular calcification was evaluated by one examiner, who was blinded to the patient characteristics. In the 56 non-DM hemodialysis patients, vascular calcification was found in the hand artery in 5 patients (8.9%) and in the aorta in 23 patients (41.1%). These levels were significantly lower (p
ISSN:0937-941X
1433-2965
DOI:10.1007/s00198-006-0154-6