Changes in amino acids and nitric oxide concentration in cerebrospinal fluid during labor pain

This study analyzes the relationship between amino acids and pain perception during active labor. Cerebrospinal fluid (CSF) levels of the excitatory amino acids (EAAs)-glutamate, aspartate and their amide forms, inhibitory amino acids (IAAs)-glycine, gamma-amino butyric acid (GABA) and taurine and n...

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Bibliographic Details
Published in:Neurochemical research 2006-09, Vol.31 (9), p.1127-1133
Main Authors: Sethuraman, Rama, Lee, Tat-Leang, Chui, Jen-Wun, Tachibana, Shinro
Format: Article
Language:English
Subjects:
Amino acids
Amino Acids - cerebrospinal fluid
Butyric acid
Cerebrospinal fluid
Childbirth & labor
Citrulline
Excitatory amino acids
Female
Glycine
Humans
Labor
Labor Pain - cerebrospinal fluid
Nitric oxide
Nitric Oxide - cerebrospinal fluid
Pain
Pain perception
Pregnancy
Taurine
γ-Aminobutyric acid
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Summary:This study analyzes the relationship between amino acids and pain perception during active labor. Cerebrospinal fluid (CSF) levels of the excitatory amino acids (EAAs)-glutamate, aspartate and their amide forms, inhibitory amino acids (IAAs)-glycine, gamma-amino butyric acid (GABA) and taurine and nitric oxide (NO) related compounds-arginine and citrulline (by-product of NO synthesis) were compared between pregnant women at term pregnancy with labor pain (n = 38) and without labor pain (Caesarian section; n = 30). The levels of aspartate, glycine, GABA and citrulline were significantly higher; whilst taurine was significantly lower in the labor pain group. These findings suggest that aspartate and NO are associated with labor pain. An inhibitory role for the IAA taurine and a pronociceptive role for glycine in labor pain are proposed.
ISSN:0364-3190
1573-6903
DOI:10.1007/s11064-006-9133-8