Incidence and clinical significance of human parvovirus B19 infection in kidney transplant recipients

:  Human parvovirus B19 (B19) infection has been known to cause chronic anemia, pure red cell aplasia (PRCA), glomerulopathy, and allograft dysfunction in kidney transplant (KT) recipients. The aim of this study was to evaluate the incidence and clinical significance of B19 infection in KT recipient...

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Bibliographic Details
Published in:Clinical transplantation 2005-12, Vol.19 (6), p.751-755
Main Authors: Ki, Chang-Seok, Kim, In-Suk, Kim, Jong-Won, Lee, Nam-Yong, Kim, Sun Hee, Lee, Kwang Woong, Kim, Sung-Joo, Joh, Jae-Won, Huh, Woo Seong, Oh, Ha Young
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
DNA, Viral - analysis
Female
Fundamental and applied biological sciences. Psychology
Fundamental immunology
Hemoglobins - analysis
Human viral diseases
Humans
Immunoglobulins, Intravenous
Incidence
Infectious diseases
kidney transplantation
Kidney Transplantation - adverse effects
Male
Medical sciences
Middle Aged
Parvoviridae Infections - diagnosis
Parvoviridae Infections - epidemiology
parvovirus B19
Parvovirus B19, Human
Polymerase Chain Reaction
pure red cell aplasia
Red-Cell Aplasia, Pure - virology
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Surgery of the urinary system
Tissue, organ and graft immunology
Viral diseases
Viral diseases with cutaneous or mucosal lesions and viral diseases of the eye
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Summary::  Human parvovirus B19 (B19) infection has been known to cause chronic anemia, pure red cell aplasia (PRCA), glomerulopathy, and allograft dysfunction in kidney transplant (KT) recipients. The aim of this study was to evaluate the incidence and clinical significance of B19 infection in KT recipients. A total of 537 serum samples from 167 KT recipients were included in the present study. The incidence of B19 infection was based on either qualitative polymerase chain reaction (PCR) or quantitative PCR with LightCycler Parvovirus B19 Quantitation kit. Clinical significance of B19 infection was investigated by a retrospective review of hemoglobin (Hb) levels and the results of kidney and bone marrow biopsies. The overall PCR positive rate was 18.3% (98/537), and 52 of 167 (31.1%) KT recipients showed at least one positive PCR. In addition, 20 of 167 subjects (12.0%) showed PCR‐positivity more than two consecutive times, and they had significantly lower Hb levels than those with negative or one positive PCR (p 
ISSN:0902-0063
1399-0012
DOI:10.1111/j.1399-0012.2005.00415.x