Systemic Oxygen Saturation and Coagulation Factor Abnormalities Before and After the Fontan Procedure

Coagulation factor abnormalities are believed to predispose to increased risk for thromboembolism after the Fontan procedure. Recent data, however, suggest that coagulation abnormalities may precede the operation. This study determined coagulation factor abnormalities in patients with single-ventric...

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Bibliographic Details
Published in:The American journal of cardiology 2005-12, Vol.96 (11), p.1571-1575
Main Authors: Cheung, Eddie W.Y., Chay, George W., Ma, Edmond S.K., Cheung, Yiu-fai
Format: Article
Language:English
Subjects:
Biological and medical sciences
Biomarkers - blood
Blood clots
Blood Coagulation Disorders - blood
Blood Coagulation Disorders - etiology
Blood Coagulation Factors - metabolism
Cardiology
Cardiology. Vascular system
Child
Comparative studies
Enzyme-Linked Immunosorbent Assay
Female
Follow-Up Studies
Fontan Procedure - adverse effects
Heart Defects, Congenital - blood
Heart Defects, Congenital - surgery
Humans
Male
Medical sciences
Oximetry
Oxygen
Oxygen - blood
Postoperative Complications - blood
Postoperative Complications - etiology
Risk Factors
Surgery
Thromboembolism - blood
Thromboembolism - etiology
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Summary:Coagulation factor abnormalities are believed to predispose to increased risk for thromboembolism after the Fontan procedure. Recent data, however, suggest that coagulation abnormalities may precede the operation. This study determined coagulation factor abnormalities in patients with single-ventricle congenital heart defects before the Fontan procedure and compared the findings with age-matched post-Fontan patients and control subjects. Liver function, coagulation factor levels, and pulse oximetry readings were determined in 11 pre-Fontan patients aged 9.3 ± 5.6 years. The results were compared with those of 11 age-matched post-Fontan patients, at 9.1 ± 2.4 years after the Fontan procedure, and 11 age-matched controls by simple analysis of variance and post hoc Tukey’s test. Liver function was normal in patients before and after surgery apart from mildly elevated bilirubin levels in post-Fontan patients (p = 0.027). When compared with controls, pre-Fontan patients had significantly lower levels of protein C; protein S; antithrombin III; and factors II, V, VII, and X and longer prothrombin times (all with p
ISSN:0002-9149
1879-1913
DOI:10.1016/j.amjcard.2005.07.074