A Powerful Brønsted Acid Catalyst for the Organocatalytic Asymmetric Transfer Hydrogenation of Imines

A little goes a long way: A 1 mol % loading of the chiral phosphoric acid catalyst 2 converts aromatic and aliphatic imines such as 1 into the corresponding amines (4) in high yields and enantioselectivities if treated with Hantzsch dihydropyridine 3.

Saved in:
Bibliographic Details
Published in:Angewandte Chemie (International ed.) 2005-12, Vol.44 (45), p.7424-7427
Main Authors: Hoffmann, Sebastian, Seayad, Abdul Majeed, List, Benjamin
Format: Article
Language:English
Subjects:
asymmetric catalysis
chiral amines
hydrogenation
imines
rhomogeneous catalysis
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A little goes a long way: A 1 mol % loading of the chiral phosphoric acid catalyst 2 converts aromatic and aliphatic imines such as 1 into the corresponding amines (4) in high yields and enantioselectivities if treated with Hantzsch dihydropyridine 3.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.200503062