Hypoadiponectinemia in Lean Lactating Women: Prolactin Inhibits Adiponectin Secretion from Human Adipocytes

Adiponectin is an adipocyte-derived hormone involved in glucose, lipid and energy metabolism. A low plasma adiponectin concentration is associated with insulin resistance, obesity and atherosclerosis. In women, energy homeostasis is remarkably changed during gestation and lactation in order to suppl...

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Bibliographic Details
Published in:ENDOCRINE JOURNAL 2006, Vol.53(4), pp.555-562
Main Authors: ASAI-SATO, Mikiko, OKAMOTO, Machi, ENDO, Masaya, YOSHIDA, Hiroshi, MURASE, Mariko, IKEDA, Mario, SAKAKIBARA, Hideya, TAKAHASHI, Tsuneo, HIRAHARA, Fumiki
Format: Article
Language:eng ; jpn
Subjects:
Adipocytes - drug effects
Adipocytes - metabolism
Adiponectin
Adiponectin - antagonists & inhibitors
Adiponectin - metabolism
Adipose Tissue - drug effects
Adipose Tissue - metabolism
Adult
Female
Humans
Japan
Lactation
Lactation - drug effects
Lactation - physiology
Longitudinal Studies
Pregnancy
Prolactin
Prolactin - pharmacology
Receptors, Prolactin - genetics
Receptors, Prolactin - metabolism
Reverse Transcriptase Polymerase Chain Reaction
RNA, Messenger - biosynthesis
RNA, Messenger - genetics
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Summary:Adiponectin is an adipocyte-derived hormone involved in glucose, lipid and energy metabolism. A low plasma adiponectin concentration is associated with insulin resistance, obesity and atherosclerosis. In women, energy homeostasis is remarkably changed during gestation and lactation in order to supply sufficient nutrition for a fetus or newborn. In this study we aimed to elucidate the physiological impact of gestation and lactation on the plasma adiponectin levels and the influence of reproduction-related hormones on adiponectin secretion. We studied the longitudinal changes in plasma adiponectin concentration during pregnancy (1st, 2nd and 3rd trimester) and lactation (3 days and 1 month after the delivery) in lean healthy women (n = 22). The plasma adiponectin level declined slightly as the pregnancy advanced and reached its lowest level during lactation (12.25 ± 0.182 μg/ml at early pregnancy vs. 6.88 ± 0.375 μg/ml at 3 days postpartum, p
ISSN:0918-8959
1348-4540
DOI:10.1507/endocrj.K06-026