Soluble oncoprotein 185HER-2 in pleural fluid has limited usefulness for the diagnostic evaluation of malignant effusions

To investigate whether pleural levels of the soluble oncoprotein 185 HER-2 (sp185(HER-2)), individually or in combination with CEA and CA 15-3, were useful for the diagnosis of malignant effusions. Levels of CEA, CA 15-3, and sp185(HER-2) were measured in the pleural fluid from 135 malignant and 103...

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Published in:Clinical biochemistry 2005-11, Vol.38 (11), p.1031-1033
Main Authors: Porcel, José Manuel, Salud, Antonieta, Vives, Manuel, Esquerda, Aureli, Rodríguez-Panadero, Francisco
Format: Article
Language:English
Subjects:
Adenocarcinoma - diagnosis
Aged
Biomarkers, Tumor - analysis
Breast Neoplasms - diagnosis
Carcinoembryonic Antigen - analysis
False Negative Reactions
Humans
Likelihood Functions
Lung Neoplasms - diagnosis
Male
Middle Aged
Mucin-1 - analysis
Pleural Effusion - chemistry
Pleural Effusion - diagnosis
Pleural Effusion, Malignant - chemistry
Pleural Effusion, Malignant - diagnosis
Receptor, ErbB-2 - analysis
Sensitivity and Specificity
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Summary:To investigate whether pleural levels of the soluble oncoprotein 185 HER-2 (sp185(HER-2)), individually or in combination with CEA and CA 15-3, were useful for the diagnosis of malignant effusions. Levels of CEA, CA 15-3, and sp185(HER-2) were measured in the pleural fluid from 135 malignant and 103 benign effusions. Thresholds of these tumor markers were chosen for a diagnostic specificity of >or=99%. Pleural sp185(HER-2) levels greater than 25 ng/mL were observed in 20% of breast and 10% of lung adenocarcinomas, and predicted a malignant effusion with a sensitivity of 7% and a likelihood ratio of 7.6. Combination of CEA and CA 15-3 resulted in 50% sensitivity, while adding sp185(HER-2) to this panel nonsignificantly increased sensitivity by 5% (P = 0.45). Only 1 patient with breast adenocarcinoma among 45 cytology-negative malignant effusions had sp185(HER-2) above the diagnostic cutoff point. Measurement of pleural fluid sp185(HER-2) has poor diagnostic performance in patients with malignant effusions.
ISSN:0009-9120
1873-2933
DOI:10.1016/j.clinbiochem.2005.05.001