The relation between insulin-like growth factor I levels and cognition in healthy elderly: A meta-analysis

Insulin-like growth factor I (IGF-I) levels and cognitive functioning decrease with aging. Several studies report positive correlations between IGF-I levels and cognitive functioning in healthy elderly. However, because of controversial data no definitive conclusions can be drawn concerning the rela...

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Bibliographic Details
Published in:Growth hormone & IGF research 2005-12, Vol.15 (6), p.416-422
Main Authors: Arwert, L.I., Deijen, J.B., Drent, M.L.
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Aging
Attention
Cognition
Cognition Disorders
Correlation
Elderly
Female
Growth Hormone
Humans
IGF-I
Insulin-Like Growth Factor Binding Protein 3 - blood
Insulin-Like Growth Factor Binding Proteins - metabolism
Insulin-Like Growth Factor I - biosynthesis
Male
Memory
Memory Disorders
Mental Status Schedule
Middle Aged
Neuropsychological Tests
Surveys and Questionnaires
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Summary:Insulin-like growth factor I (IGF-I) levels and cognitive functioning decrease with aging. Several studies report positive correlations between IGF-I levels and cognitive functioning in healthy elderly. However, because of controversial data no definitive conclusions can be drawn concerning the relation between IGF-I and cognition. Therefore, we carried out a meta-analysis on studies that report on the relation between IGF-I and cognition in healthy elderly. We searched the electronic databases for articles about IGF-I and cognition. Studies from 1985 to January 2005 are included. Two reviewers independently extracted data on study design and cognitive outcomes. Thirteen studies on IGF-I and cognition in elderly, with a total number of 1981 subjects, met the inclusion criteria. On the data from these studies meta-analyses were carried out by means of the program Comprehensive Meta-analysis using a random effects model. Pooled effects show that IGF-I levels in healthy elderly have a positive correlation with cognitive functioning, which appeared to be mainly measured with the mini mental state examination (MMSE). The effect size is 0.6, which indicates the presence of a large positive relationship between IGF and cognition in healthy elderly. These meta-analyses showed an overall relationship between IGF-I levels and cognitive functioning in healthy elderly. Further studies should be performed to clarify the role of IGF-I substitution in preserving cognitive functions with aging.
ISSN:1096-6374
1532-2238
DOI:10.1016/j.ghir.2005.09.001