Electrophysiological findings in a cohort of old polio survivors

A population‐based cohort of poliomyelitis survivors was established and followed for 15 years (mean time since polio was 40 years). Over time, the cohort demonstrated a modest decline in summated compound muscle action potential amplitudes (CMAP) and a moderate decline in the summated motor unit nu...

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Bibliographic Details
Published in:Journal of the peripheral nervous system 2006-09, Vol.11 (3), p.241-246
Main Authors: Sorenson, Eric J., Daube, Jasper R., Windebank, Anthony J.
Format: Article
Language:English
Subjects:
Action Potentials - physiology
Adult
Aged
Analysis of Variance
Cohort Studies
electrophysiology
Electrophysiology - methods
epidemiology
Female
Humans
Male
Middle Aged
Motor Neurons - physiology
Muscle Contraction - physiology
Muscle, Skeletal - physiopathology
neuromuscular disease
poliomyelitis
Postpoliomyelitis Syndrome - mortality
Postpoliomyelitis Syndrome - physiopathology
Retrospective Studies
Time Factors
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Summary:A population‐based cohort of poliomyelitis survivors was established and followed for 15 years (mean time since polio was 40 years). Over time, the cohort demonstrated a modest decline in summated compound muscle action potential amplitudes (CMAP) and a moderate decline in the summated motor unit number estimates (MUNE). There was no association between symptoms of late deterioration and magnitude of decline. Rather, the presence of these symptoms was associated with the magnitude of the residual deficits. Two patterns of neuron loss were modeled (linear and proportional decline). The summated MUNE was a more sensitive measure of loss of motor units than was the summated CMAP and appears to be a more valid measure of attritional loss of anterior horn cells. Of these two models of neuron loss, the proportional loss of motor neurons was a better fit of the data than a linear loss.
ISSN:1085-9489
1529-8027
DOI:10.1111/j.1529-8027.2006.00094.x