Nitric oxide and antioxidant defense in patients with gastric cancer

In the present study, total nitrate and nitrite level (as end product of nitric oxide), superoxide dismutase activity, and glutathione peroxidase activity in leukocytes were determined in patients with gastric cancer, and the relationship between measured parameters and tumor grade were evaluated. L...

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Bibliographic Details
Published in:Digestive diseases and sciences 2006-08, Vol.51 (8), p.1367-1370
Main Authors: DINCER, Yildiz, AKCAY, Tülay, TORTUM, Osman B, DOGUSOY, Gulen
Format: Article
Language:English
Subjects:
Antioxidants - metabolism
Biological and medical sciences
Biomarkers - blood
Disease Progression
Feeding. Feeding behavior
Female
Fundamental and applied biological sciences. Psychology
Gastroenterology. Liver. Pancreas. Abdomen
Glutathione Peroxidase - blood
Humans
Leukocytes - metabolism
Male
Medical sciences
Middle Aged
Neoplasm Staging
Nitrates - blood
Nitric Oxide - blood
Nitrites - blood
Severity of Illness Index
Stomach Neoplasms - blood
Stomach Neoplasms - pathology
Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
Superoxide Dismutase - blood
Tumors
Vertebrates: anatomy and physiology, studies on body, several organs or systems
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Summary:In the present study, total nitrate and nitrite level (as end product of nitric oxide), superoxide dismutase activity, and glutathione peroxidase activity in leukocytes were determined in patients with gastric cancer, and the relationship between measured parameters and tumor grade were evaluated. Leukocyte nitrate and nitrite level was found to be increased and superoxide dismutase activity was found to be decreased in patients compared to controls. When the patient group was categorized, nitrate and nitrite level was found to be higher in patients with a high-grade tumor than in patients with a grade I tumor. We concluded that an increased level of leukocyte nitrate and nitrite is related to tumor grade in patients with gastric cancer; antioxidant activity is also impaired in these patients but it does not seem to be related to grade of tumor.
ISSN:0163-2116
1573-2568
DOI:10.1007/s10620-005-9021-0