Loading…
Characterization of blood components prepared from whole-blood donations after a 24-hour hold with the platelet-rich plasma method
BACKGROUND: The preparation of platelet (PLT) concentrates (PCs) from PLT‐rich plasma (PRP) requires that whole blood (WB) be processed within 8 hours of collection. Increasing WB storage time to 24 hours would be logistically attractive. This study compares the in vitro quality of blood components...
Saved in:
| Published in: | Transfusion (Philadelphia, Pa.) Pa.), 2006-08, Vol.46 (8), p.1292-1299 |
|---|---|
| Main Authors: | , , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that this one cites Items that cite this one |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | cdi_FETCH-LOGICAL-c4364-b23221b5a1e6de86639f8019da1570742c76542947c429f457304e1efe1924e73 |
|---|---|
| cites | cdi_FETCH-LOGICAL-c4364-b23221b5a1e6de86639f8019da1570742c76542947c429f457304e1efe1924e73 |
| container_end_page | 1299 |
| container_issue | 8 |
| container_start_page | 1292 |
| container_title | Transfusion (Philadelphia, Pa.) |
| container_volume | 46 |
| creator | Thibault, Louis Beauséjour, Annie De Grandmont, Marie Joëlle Lemieux, Réal Leblanc, Jean-François |
| description | BACKGROUND: The preparation of platelet (PLT) concentrates (PCs) from PLT‐rich plasma (PRP) requires that whole blood (WB) be processed within 8 hours of collection. Increasing WB storage time to 24 hours would be logistically attractive. This study compares the in vitro quality of blood components prepared from WB stored for 8 and 24 hours at room temperature before processing with the PRP method.
STUDY DESIGN AND METHODS: WB units were collected from ABO‐matched blood donors. To reduce individual variations, paired donations were drawn in parallel, pooled, and split back in the collection bag. One unit was held for 6 to 8 hours and the other for 22 to 24 hours at 20 to 24°C. Prestorage leukoreduced components were prepared with the PRP as intermediate product and analyzed during storage.
RESULTS: RBC units prepared after an 8‐ or 24‐hour hold were comparable in terms of hemolysis, sodium, pH, and ATP levels. RBC 2,3‐ diphosphoglycerate (2,3‐DPG) was significantly lower in RBCs prepared from 24‐hour hold donations immediately after processing but not after 20 days of storage. Residual white blood cells were approximately fivefold higher (p |
| doi_str_mv | 10.1111/j.1537-2995.2006.00894.x |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_68787439</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>68787439</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4364-b23221b5a1e6de86639f8019da1570742c76542947c429f457304e1efe1924e73</originalsourceid><addsrcrecordid>eNqNkE1v0zAchy0EYmXwFZAvcEvwW-z4goQKG0hTkabBjpbr_KOkJHGwXbXjyCcnaartig9-kZ_fz9aDEKYkp9P4sMtpwVXGtC5yRojMCSm1yI_P0Orx4jlaESJoRilnF-hVjDtCCNOEvkQXVGouiGQr9Hfd2GBdgtD-san1A_Y13nbeV9j5fvQDDCniMcBoA1S4Dr7Hh8Z3kC1Q5YdTLGJbTyXYYiayxu8DnqAKH9rU4NQAHjuboIOUhdY18yn2FveQGl-9Ri9q20V4c14v0Y-rL3frr9nN9-tv6083mRNcimzLOGN0W1gKsoJSSq7rklBdWVooogRzShaCaaHcNNeiUJwIoFAD1UyA4pfo_dI7Bv97DzGZvo0Ous4O4PfRyFKVSnA9geUCuuBjDFCbMbS9DQ-GEjP7NzszazazZjP7Nyf_5jhF357f2G97qJ6CZ-ET8O4M2OhsVwc7uDY-cSXhBSdy4j4u3KHt4OG_P2Dubq9O26kgWwramOD4WGDDLyMVV4W531wbxu8_05-bW7Ph_wAyUrDV</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>68787439</pqid></control><display><type>article</type><title>Characterization of blood components prepared from whole-blood donations after a 24-hour hold with the platelet-rich plasma method</title><source>Wiley-Blackwell Read & Publish Collection</source><creator>Thibault, Louis ; Beauséjour, Annie ; De Grandmont, Marie Joëlle ; Lemieux, Réal ; Leblanc, Jean-François</creator><creatorcontrib>Thibault, Louis ; Beauséjour, Annie ; De Grandmont, Marie Joëlle ; Lemieux, Réal ; Leblanc, Jean-François</creatorcontrib><description>BACKGROUND: The preparation of platelet (PLT) concentrates (PCs) from PLT‐rich plasma (PRP) requires that whole blood (WB) be processed within 8 hours of collection. Increasing WB storage time to 24 hours would be logistically attractive. This study compares the in vitro quality of blood components prepared from WB stored for 8 and 24 hours at room temperature before processing with the PRP method.
STUDY DESIGN AND METHODS: WB units were collected from ABO‐matched blood donors. To reduce individual variations, paired donations were drawn in parallel, pooled, and split back in the collection bag. One unit was held for 6 to 8 hours and the other for 22 to 24 hours at 20 to 24°C. Prestorage leukoreduced components were prepared with the PRP as intermediate product and analyzed during storage.
RESULTS: RBC units prepared after an 8‐ or 24‐hour hold were comparable in terms of hemolysis, sodium, pH, and ATP levels. RBC 2,3‐ diphosphoglycerate (2,3‐DPG) was significantly lower in RBCs prepared from 24‐hour hold donations immediately after processing but not after 20 days of storage. Residual white blood cells were approximately fivefold higher (p < 0.05) in 24‐hour RBC units. For PCs, measurements for glucose, ATP, lactate, pH, extent of shape change, hypotonic shock response, and CD62p activation were similar. No differences were observed in the von Willebrand factor, factor (F)V, FVIII, and fibrinogen content of fresh‐frozen plasma.
CONCLUSIONS: The decrease in FVIII and RBC 2,3‐DPG can be acceptable as a compromise to improve blood component logistics, but leukoreduction efficiency must be improved before considering the adoption of an overnight storage of WB before PRP processing.</description><identifier>ISSN: 0041-1132</identifier><identifier>EISSN: 1537-2995</identifier><identifier>DOI: 10.1111/j.1537-2995.2006.00894.x</identifier><identifier>PMID: 16934062</identifier><identifier>CODEN: TRANAT</identifier><language>eng</language><publisher>Malden, USA: Blackwell Publishing Inc</publisher><subject>ABO Blood-Group System ; Adenosine Triphosphate - blood ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Biological and medical sciences ; Blood Coagulation Factors - analysis ; Blood coagulation. Blood cells ; Blood Donors ; Blood Glucose - analysis ; Blood Platelets - metabolism ; Blood Specimen Collection - methods ; Blood. Blood and plasma substitutes. Blood products. Blood cells. Blood typing. Plasmapheresis. Apheresis ; E-Selectin - blood ; Emergency and intensive cardiocirculatory care. Cardiogenic shock. Coronary intensive care ; Female ; Fundamental and applied biological sciences. Psychology ; Hemolysis ; Humans ; Intensive care medicine ; Leukocyte Reduction Procedures - methods ; Leukocytes - metabolism ; Male ; Medical sciences ; Molecular and cellular biology ; Plasma ; Platelet ; Time Factors ; Transfusions. Complications. Transfusion reactions. Cell and gene therapy</subject><ispartof>Transfusion (Philadelphia, Pa.), 2006-08, Vol.46 (8), p.1292-1299</ispartof><rights>2006 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4364-b23221b5a1e6de86639f8019da1570742c76542947c429f457304e1efe1924e73</citedby><cites>FETCH-LOGICAL-c4364-b23221b5a1e6de86639f8019da1570742c76542947c429f457304e1efe1924e73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,783,787,27936,27937</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18035306$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16934062$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Thibault, Louis</creatorcontrib><creatorcontrib>Beauséjour, Annie</creatorcontrib><creatorcontrib>De Grandmont, Marie Joëlle</creatorcontrib><creatorcontrib>Lemieux, Réal</creatorcontrib><creatorcontrib>Leblanc, Jean-François</creatorcontrib><title>Characterization of blood components prepared from whole-blood donations after a 24-hour hold with the platelet-rich plasma method</title><title>Transfusion (Philadelphia, Pa.)</title><addtitle>Transfusion</addtitle><description>BACKGROUND: The preparation of platelet (PLT) concentrates (PCs) from PLT‐rich plasma (PRP) requires that whole blood (WB) be processed within 8 hours of collection. Increasing WB storage time to 24 hours would be logistically attractive. This study compares the in vitro quality of blood components prepared from WB stored for 8 and 24 hours at room temperature before processing with the PRP method.
STUDY DESIGN AND METHODS: WB units were collected from ABO‐matched blood donors. To reduce individual variations, paired donations were drawn in parallel, pooled, and split back in the collection bag. One unit was held for 6 to 8 hours and the other for 22 to 24 hours at 20 to 24°C. Prestorage leukoreduced components were prepared with the PRP as intermediate product and analyzed during storage.
RESULTS: RBC units prepared after an 8‐ or 24‐hour hold were comparable in terms of hemolysis, sodium, pH, and ATP levels. RBC 2,3‐ diphosphoglycerate (2,3‐DPG) was significantly lower in RBCs prepared from 24‐hour hold donations immediately after processing but not after 20 days of storage. Residual white blood cells were approximately fivefold higher (p < 0.05) in 24‐hour RBC units. For PCs, measurements for glucose, ATP, lactate, pH, extent of shape change, hypotonic shock response, and CD62p activation were similar. No differences were observed in the von Willebrand factor, factor (F)V, FVIII, and fibrinogen content of fresh‐frozen plasma.
CONCLUSIONS: The decrease in FVIII and RBC 2,3‐DPG can be acceptable as a compromise to improve blood component logistics, but leukoreduction efficiency must be improved before considering the adoption of an overnight storage of WB before PRP processing.</description><subject>ABO Blood-Group System</subject><subject>Adenosine Triphosphate - blood</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Biological and medical sciences</subject><subject>Blood Coagulation Factors - analysis</subject><subject>Blood coagulation. Blood cells</subject><subject>Blood Donors</subject><subject>Blood Glucose - analysis</subject><subject>Blood Platelets - metabolism</subject><subject>Blood Specimen Collection - methods</subject><subject>Blood. Blood and plasma substitutes. Blood products. Blood cells. Blood typing. Plasmapheresis. Apheresis</subject><subject>E-Selectin - blood</subject><subject>Emergency and intensive cardiocirculatory care. Cardiogenic shock. Coronary intensive care</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hemolysis</subject><subject>Humans</subject><subject>Intensive care medicine</subject><subject>Leukocyte Reduction Procedures - methods</subject><subject>Leukocytes - metabolism</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Molecular and cellular biology</subject><subject>Plasma</subject><subject>Platelet</subject><subject>Time Factors</subject><subject>Transfusions. Complications. Transfusion reactions. Cell and gene therapy</subject><issn>0041-1132</issn><issn>1537-2995</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><recordid>eNqNkE1v0zAchy0EYmXwFZAvcEvwW-z4goQKG0hTkabBjpbr_KOkJHGwXbXjyCcnaartig9-kZ_fz9aDEKYkp9P4sMtpwVXGtC5yRojMCSm1yI_P0Orx4jlaESJoRilnF-hVjDtCCNOEvkQXVGouiGQr9Hfd2GBdgtD-san1A_Y13nbeV9j5fvQDDCniMcBoA1S4Dr7Hh8Z3kC1Q5YdTLGJbTyXYYiayxu8DnqAKH9rU4NQAHjuboIOUhdY18yn2FveQGl-9Ri9q20V4c14v0Y-rL3frr9nN9-tv6083mRNcimzLOGN0W1gKsoJSSq7rklBdWVooogRzShaCaaHcNNeiUJwIoFAD1UyA4pfo_dI7Bv97DzGZvo0Ous4O4PfRyFKVSnA9geUCuuBjDFCbMbS9DQ-GEjP7NzszazazZjP7Nyf_5jhF357f2G97qJ6CZ-ET8O4M2OhsVwc7uDY-cSXhBSdy4j4u3KHt4OG_P2Dubq9O26kgWwramOD4WGDDLyMVV4W531wbxu8_05-bW7Ph_wAyUrDV</recordid><startdate>200608</startdate><enddate>200608</enddate><creator>Thibault, Louis</creator><creator>Beauséjour, Annie</creator><creator>De Grandmont, Marie Joëlle</creator><creator>Lemieux, Réal</creator><creator>Leblanc, Jean-François</creator><general>Blackwell Publishing Inc</general><general>Blackwell Publishing</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200608</creationdate><title>Characterization of blood components prepared from whole-blood donations after a 24-hour hold with the platelet-rich plasma method</title><author>Thibault, Louis ; Beauséjour, Annie ; De Grandmont, Marie Joëlle ; Lemieux, Réal ; Leblanc, Jean-François</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4364-b23221b5a1e6de86639f8019da1570742c76542947c429f457304e1efe1924e73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>ABO Blood-Group System</topic><topic>Adenosine Triphosphate - blood</topic><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Biological and medical sciences</topic><topic>Blood Coagulation Factors - analysis</topic><topic>Blood coagulation. Blood cells</topic><topic>Blood Donors</topic><topic>Blood Glucose - analysis</topic><topic>Blood Platelets - metabolism</topic><topic>Blood Specimen Collection - methods</topic><topic>Blood. Blood and plasma substitutes. Blood products. Blood cells. Blood typing. Plasmapheresis. Apheresis</topic><topic>E-Selectin - blood</topic><topic>Emergency and intensive cardiocirculatory care. Cardiogenic shock. Coronary intensive care</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Hemolysis</topic><topic>Humans</topic><topic>Intensive care medicine</topic><topic>Leukocyte Reduction Procedures - methods</topic><topic>Leukocytes - metabolism</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Molecular and cellular biology</topic><topic>Plasma</topic><topic>Platelet</topic><topic>Time Factors</topic><topic>Transfusions. Complications. Transfusion reactions. Cell and gene therapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Thibault, Louis</creatorcontrib><creatorcontrib>Beauséjour, Annie</creatorcontrib><creatorcontrib>De Grandmont, Marie Joëlle</creatorcontrib><creatorcontrib>Lemieux, Réal</creatorcontrib><creatorcontrib>Leblanc, Jean-François</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Transfusion (Philadelphia, Pa.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Thibault, Louis</au><au>Beauséjour, Annie</au><au>De Grandmont, Marie Joëlle</au><au>Lemieux, Réal</au><au>Leblanc, Jean-François</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Characterization of blood components prepared from whole-blood donations after a 24-hour hold with the platelet-rich plasma method</atitle><jtitle>Transfusion (Philadelphia, Pa.)</jtitle><addtitle>Transfusion</addtitle><date>2006-08</date><risdate>2006</risdate><volume>46</volume><issue>8</issue><spage>1292</spage><epage>1299</epage><pages>1292-1299</pages><issn>0041-1132</issn><eissn>1537-2995</eissn><coden>TRANAT</coden><abstract>BACKGROUND: The preparation of platelet (PLT) concentrates (PCs) from PLT‐rich plasma (PRP) requires that whole blood (WB) be processed within 8 hours of collection. Increasing WB storage time to 24 hours would be logistically attractive. This study compares the in vitro quality of blood components prepared from WB stored for 8 and 24 hours at room temperature before processing with the PRP method.
STUDY DESIGN AND METHODS: WB units were collected from ABO‐matched blood donors. To reduce individual variations, paired donations were drawn in parallel, pooled, and split back in the collection bag. One unit was held for 6 to 8 hours and the other for 22 to 24 hours at 20 to 24°C. Prestorage leukoreduced components were prepared with the PRP as intermediate product and analyzed during storage.
RESULTS: RBC units prepared after an 8‐ or 24‐hour hold were comparable in terms of hemolysis, sodium, pH, and ATP levels. RBC 2,3‐ diphosphoglycerate (2,3‐DPG) was significantly lower in RBCs prepared from 24‐hour hold donations immediately after processing but not after 20 days of storage. Residual white blood cells were approximately fivefold higher (p < 0.05) in 24‐hour RBC units. For PCs, measurements for glucose, ATP, lactate, pH, extent of shape change, hypotonic shock response, and CD62p activation were similar. No differences were observed in the von Willebrand factor, factor (F)V, FVIII, and fibrinogen content of fresh‐frozen plasma.
CONCLUSIONS: The decrease in FVIII and RBC 2,3‐DPG can be acceptable as a compromise to improve blood component logistics, but leukoreduction efficiency must be improved before considering the adoption of an overnight storage of WB before PRP processing.</abstract><cop>Malden, USA</cop><pub>Blackwell Publishing Inc</pub><pmid>16934062</pmid><doi>10.1111/j.1537-2995.2006.00894.x</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0041-1132 |
| ispartof | Transfusion (Philadelphia, Pa.), 2006-08, Vol.46 (8), p.1292-1299 |
| issn | 0041-1132 1537-2995 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_68787439 |
| source | Wiley-Blackwell Read & Publish Collection |
| subjects | ABO Blood-Group System Adenosine Triphosphate - blood Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Biological and medical sciences Blood Coagulation Factors - analysis Blood coagulation. Blood cells Blood Donors Blood Glucose - analysis Blood Platelets - metabolism Blood Specimen Collection - methods Blood. Blood and plasma substitutes. Blood products. Blood cells. Blood typing. Plasmapheresis. Apheresis E-Selectin - blood Emergency and intensive cardiocirculatory care. Cardiogenic shock. Coronary intensive care Female Fundamental and applied biological sciences. Psychology Hemolysis Humans Intensive care medicine Leukocyte Reduction Procedures - methods Leukocytes - metabolism Male Medical sciences Molecular and cellular biology Plasma Platelet Time Factors Transfusions. Complications. Transfusion reactions. Cell and gene therapy |
| title | Characterization of blood components prepared from whole-blood donations after a 24-hour hold with the platelet-rich plasma method |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-11-16T02%3A30%3A46IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Characterization%20of%20blood%20components%20prepared%20from%20whole-blood%20donations%20after%20a%2024-hour%20hold%20with%20the%20platelet-rich%20plasma%20method&rft.jtitle=Transfusion%20(Philadelphia,%20Pa.)&rft.au=Thibault,%20Louis&rft.date=2006-08&rft.volume=46&rft.issue=8&rft.spage=1292&rft.epage=1299&rft.pages=1292-1299&rft.issn=0041-1132&rft.eissn=1537-2995&rft.coden=TRANAT&rft_id=info:doi/10.1111/j.1537-2995.2006.00894.x&rft_dat=%3Cproquest_cross%3E68787439%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c4364-b23221b5a1e6de86639f8019da1570742c76542947c429f457304e1efe1924e73%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=68787439&rft_id=info:pmid/16934062&rfr_iscdi=true |