Methodological issues in the assessment of skin microvascular endothelial function in humans

The study of microvascular function can be performed in humans using laser Doppler flowmetry of the skin. This technology lends itself to a wide range of applications for studying the endothelial function of skin blood vessels. We review the advantages and limitations of postocclusive hyperemia, loc...

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Bibliographic Details
Published in:Trends in pharmacological sciences (Regular ed.) 2006-09, Vol.27 (9), p.503-508
Main Authors: Cracowski, Jean-Luc, Minson, Christopher T., Salvat-Melis, Muriel, Halliwill, John R.
Format: Article
Language:English
Subjects:
Acetylcholine - administration & dosage
Animals
Biomarkers
Endothelium, Vascular - physiology
Humans
Hyperemia - physiopathology
Iontophoresis
Laser-Doppler Flowmetry
Microcirculation
Microdialysis
Regional Blood Flow
Skin - blood supply
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Summary:The study of microvascular function can be performed in humans using laser Doppler flowmetry of the skin. This technology lends itself to a wide range of applications for studying the endothelial function of skin blood vessels. We review the advantages and limitations of postocclusive hyperemia, local thermal hyperemia, acetylcholine iontophoresis, flowmotion and association with microdialysis as tools with which to investigate skin microvascular endothelial function in humans. Postocclusive hyperemia, thermal hyperemia and acetylcholine iontophoresis provide integrated indexes of microvascular function rather than specific endothelial markers. However, they are valuable tools and can be used as surrogate endpoints in clinical trials in which the assessment of microvascular function in humans is required.
ISSN:0165-6147
1873-3735
DOI:10.1016/j.tips.2006.07.008