Different clinical features of primary and secondary tumors in patients with multiple malignancies

Clinical features of the first and second primaries in patients with multiple malignancies have not been extensively studied. We compared patient and treatment characteristics of the primary malignancy in 48 consequent multiple primary cancer patients with those of the second primary in the same coh...

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Bibliographic Details
Published in:Tumori 2005-07, Vol.91 (4), p.317-320
Main Authors: Artac, Mehmet, Bozcuk, Hakan, Ozdogan, Mustafa, Demiral, Ayşe Nur, Sarper, Alpay, Samur, Mustafa, Savas, Burhan
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Breast Neoplasms - diagnosis
Female
Humans
Male
Middle Aged
Neoplasm Staging
Neoplasms, Multiple Primary - diagnosis
Neoplasms, Multiple Primary - pathology
Neoplasms, Second Primary - diagnosis
Neoplasms, Second Primary - pathology
Prognosis
Survival Analysis
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Summary:Clinical features of the first and second primaries in patients with multiple malignancies have not been extensively studied. We compared patient and treatment characteristics of the primary malignancy in 48 consequent multiple primary cancer patients with those of the second primary in the same cohort. The second primaries comprised fewer breast cancers; 29.2% of primaries as opposed to 10.4% of second tumors were breast cancer (P = 0.049). In addition, primary tumors tended to be at a lower TNM stage than secondary tumors (P = 0.060). The median overall survival after the diagnosis of the first primary for the whole cohort was 22.3 years (95% CI, 2.0-42.5) and the median time to presentation of the second malignancy was 38 months after the diagnosis of the first primary (range, 0 to 384). Therefore, the prognosis of cancers in the multiple malignancy group appears to be good and they appear to have an indolent clinical behavior. Thus, we recommend a long screening time for secondary tumors after a curative treatment in patients with common cancers, taking into account the different occurrence patterns of second primaries with respect to first primaries.
ISSN:0300-8916
2038-2529
DOI:10.1177/030089160509100406