Reduced Anterior Cingulate Glutamate in Pediatric Major Depression: A Magnetic Resonance Spectroscopy Study

Anterior cingulate cortex has been implicated in the pathogenesis of major depressive disorder (MDD). With single voxel proton magnetic resonance spectroscopy, we reported reductions in anterior cingulate glutamatergic concentrations (grouped value of glutamate and glutamine) in 14 pediatric MDD pat...

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Bibliographic Details
Published in:Biological psychiatry (1969) 2005-11, Vol.58 (9), p.700-704
Main Authors: Rosenberg, David R., MacMaster, Frank P., Mirza, Yousha, Smith, Janet M., Easter, Phillip C., Banerjee, S. Preeya, Bhandari, Rashmi, Boyd, Courtney, Lynch, Michelle, Rose, Michelle, Ivey, Jennifer, Villafuerte, Rosemond A., Moore, Gregory J., Renshaw, Perry
Format: Article
Language:English
Subjects:
Adolescent
Anterior cingulate cortex
Biological and medical sciences
Brain Chemistry
child
Child clinical studies
depression
Depressive Disorder, Major - metabolism
Depressive Disorder, Major - pathology
Female
glutamate
Glutamic Acid - metabolism
Glutamine - metabolism
Gyrus Cinguli - metabolism
Gyrus Cinguli - pathology
Humans
Magnetic Resonance Spectroscopy
Male
Medical sciences
Mood disorders
proton magnetic resonance spectroscopy
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
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Summary:Anterior cingulate cortex has been implicated in the pathogenesis of major depressive disorder (MDD). With single voxel proton magnetic resonance spectroscopy, we reported reductions in anterior cingulate glutamatergic concentrations (grouped value of glutamate and glutamine) in 14 pediatric MDD patients versus 14 case-matched healthy control subjects. These changes might reflect a change in glutamate, glutamine, or their combination. Fitting to individually quantify anterior cingulate glutamate and glutamine was performed in these subjects with a new basis set created from data acquired on a 1.5 Tesla General Electric Signa (GE Healthcare, Waukesha, Wisconsin) magnetic resonance imaging scanner with LCModel (Version 6.1-0; Max-Planck-Institute, Gottingen, Germany). Reduced anterior cingulate glutamate was observed in MDD patients versus control subjects (8.79 ± 1.68 vs. 11.46 ± 1.55, respectively, p = .0002; 23% decrease). Anterior cingulate glutamine did not differ significantly between patients with MDD and control subjects. These findings provide confirmatory evidence of anterior cingulate glutamate alterations in pediatric MDD.
ISSN:0006-3223
1873-2402
DOI:10.1016/j.biopsych.2005.05.007