Catalytic Asymmetric Esterification of Ketenes

Ketene esterification after 100 years: In the latest advance in the esterification of ketenes, Schaefer and Fu described the catalytic asymmetric conversion of 2‐tolyl(ethyl)ketene (1) and diphenylacetaldehyde to give the enol ester 2 in 99 % yield and 98 % ee (see scheme).

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Bibliographic Details
Published in:Angewandte Chemie (International ed.) 2005-10, Vol.44 (42), p.6812-6814
Main Author: Tidwell, Thomas T.
Format: Article
Language:English
Subjects:
asymmetric catalysis
Catalysis
enol esters
Esterification
Ethylenes - chemical synthesis
Ethylenes - chemistry
homogeneous catalysis
ketenes
Ketones - chemical synthesis
Ketones - chemistry
Molecular Structure
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Description
Summary:Ketene esterification after 100 years: In the latest advance in the esterification of ketenes, Schaefer and Fu described the catalytic asymmetric conversion of 2‐tolyl(ethyl)ketene (1) and diphenylacetaldehyde to give the enol ester 2 in 99 % yield and 98 % ee (see scheme).
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.200501849