Is melanocytic nevus with focal atypical epithelioid components (clonal nevus) a superficial variant of deep penetrating nevus?

We compare features of two similar nevi which may be confused with melanoma: deep penetrating nevus (DPN), and nevus with focal atypical epithelioid component (NFAEC). Clinical/demographic and histologic information regarding 146 DPN and 81 NFAEC were compared. Patient outcomes were ascertained via...

Full description

Saved in:
Bibliographic Details
Published in:Journal of the American Academy of Dermatology 2006-09, Vol.55 (3), p.460-466
Main Authors: High, Whitney A., Alanen, Kenneth W., Golitz, Loren E.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Biological and medical sciences
Cell Nucleus - metabolism
Child
Child, Preschool
Dermatology
Dermis - pathology
Female
Humans
Immunohistochemistry
Male
Medical sciences
Middle Aged
Mitosis
Neoplasm Invasiveness - pathology
Nevus, Pigmented - classification
Nevus, Pigmented - metabolism
Nevus, Pigmented - pathology
Retrospective Studies
Skin Neoplasms - classification
Skin Neoplasms - metabolism
Skin Neoplasms - pathology
Subcutaneous Tissue - pathology
Tissue Distribution
Tumor Suppressor Protein p53 - metabolism
Tumors of the skin and soft tissue. Premalignant lesions
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:We compare features of two similar nevi which may be confused with melanoma: deep penetrating nevus (DPN), and nevus with focal atypical epithelioid component (NFAEC). Clinical/demographic and histologic information regarding 146 DPN and 81 NFAEC were compared. Patient outcomes were ascertained via a questionnaire solicited to the referring physicians. Clinical features were similar for each type of nevus. Histologically, all lesions demonstrated identical aggregates of epithelioid melanocytes. DPN more often extended into the deep dermis or subcutaneous tissue, while NFAEC was typically confined to the superficial dermis. NFAEC more often demonstrated a junctional component ( P < .001) and coexistent common nevus with congenital features ( P = .035). DPN more often demonstrated adnexal spread ( P < .001). A subgroup with overlapping features was identified. With an average of 6.4 years follow-up, there were just two recurrences, and no metastases. This retrospective study utilized tissue specimens from a single reference laboratory; ergo, some inherent selection bias exists. Specimens were randomly selected for P53 immunostaining, leading also to potential sampling error. DPN and NFAEC show considerable similarity, differing mainly in the depth of extent for the lesion. It is possible that NFAEC represents a more superficial variant of DPN. A subgroup with overlapping features, but intermediate depth, supports such a relationship.
ISSN:0190-9622
1097-6787
DOI:10.1016/j.jaad.2006.04.054