Parathyroid carcinoma

Background: Parathyroid carcinoma is a rare malignancy affecting 0·5–5 per cent of all patients with primary hyperparathyroidism. This article reviews the literature on the pathogenesis, pathology, clinical features, diagnosis and management of parathyroid carcinoma. Methods: A Medline search was pe...

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Bibliographic Details
Published in:British journal of surgery 2005-11, Vol.92 (11), p.1345-1353
Main Authors: Rawat, N., Khetan, N., Williams, D. W., Baxter, J. N.
Format: Article
Language:English
Subjects:
Biological and medical sciences
Combined Modality Therapy
General aspects
Humans
Medical sciences
Neoplasm Recurrence, Local - therapy
Parathyroid Neoplasms - diagnosis
Parathyroid Neoplasms - etiology
Parathyroid Neoplasms - therapy
Treatment Outcome
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Summary:Background: Parathyroid carcinoma is a rare malignancy affecting 0·5–5 per cent of all patients with primary hyperparathyroidism. This article reviews the literature on the pathogenesis, pathology, clinical features, diagnosis and management of parathyroid carcinoma. Methods: A Medline search was performed and all relevant English language articles published between 1970 and 2005 were retrieved. The search words included ‘parathyroid carcinoma’, ‘pathology’, ‘genetics’, ‘management’ and ‘radiotherapy’. Secondary references were obtained from key articles. Results and conclusion: The exact aetiology of parathyroid carcinoma remains obscure. Recently, the HRPT2 gene has been implicated in its pathogenesis and may prove to be a genetic target in future. Surgical resection is the accepted ‘gold standard’. There is now a growing consensus on the use of adjuvant radiotherapy as it has been shown to provide a survival benefit. Copyright © 2005 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd. May be radiosensitive after all
ISSN:0007-1323
1365-2168
DOI:10.1002/bjs.5182