Prevalence of Plasmodium falciparum cytochrome b gene mutations in isolates imported from Africa, and implications for atovaquone resistance

The atovaquone resistance of malaria parasites correlates with mutations in the cytochrome b gene. We sequenced the Plasmodium falciparum cytochrome b gene of 135 African isolates. Our data showed a high mutation rate (8.9%); however, the risk of emergence spreading of atovaquone-resistant P. falcip...

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Bibliographic Details
Published in:Transactions of the Royal Society of Tropical Medicine and Hygiene 2006-10, Vol.100 (10), p.986-988
Main Authors: Berry, A., Senescau, A., Lelièvre, J., Benoit-Vical, F., Fabre, R., Marchou, B., Magnaval, J.F.
Format: Article
Language:English
Subjects:
Africa
Amino Acid Sequence
Animals
Antimalarials - therapeutic use
Atovaquone
Atovaquone - therapeutic use
Biological and medical sciences
Cytochrome b
Cytochromes b - genetics
Drug Resistance
Emigration and Immigration
Human protozoal diseases
Humans
Infectious diseases
Malaria
Malaria, Falciparum - drug therapy
Malaria, Falciparum - genetics
Medical sciences
Mutation - genetics
Mutations
Parasitic diseases
Plasmodium falciparum
Plasmodium falciparum - genetics
Polymerase Chain Reaction
Proguanil
Protozoal diseases
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Summary:The atovaquone resistance of malaria parasites correlates with mutations in the cytochrome b gene. We sequenced the Plasmodium falciparum cytochrome b gene of 135 African isolates. Our data showed a high mutation rate (8.9%); however, the risk of emergence spreading of atovaquone-resistant P. falciparum strains could be limited.
ISSN:0035-9203
1878-3503
DOI:10.1016/j.trstmh.2006.02.004