The distribution of serotonergic fibers in the macaque monkey amygdala: An immunohistochemical study using antisera to 5-hydroxytryptamine

Though both the amygdala and the serotonin system appear to play critical roles in regulating fear and anxiety, little is known regarding the organization of serotonergic inputs to the primate amygdala. The present study employed immunohistochemistry to determine the distribution of serotonin fibers...

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Bibliographic Details
Published in:Neuroscience 2005, Vol.136 (1), p.193-203
Main Authors: Bauman, M.D., Amaral, D.G.
Format: Article
Language:English
Subjects:
Amygdala - metabolism
Amygdala - ultrastructure
amygdaloid complex
Animals
Biological and medical sciences
Central nervous system
Central neurotransmission. Neuromudulation. Pathways and receptors
Fundamental and applied biological sciences. Psychology
Immune Sera
Immunohistochemistry
Macaca fascicularis
Male
Nerve Fibers - metabolism
Nerve Fibers - ultrastructure
Photomicrography
primate
serotonin
Serotonin - immunology
Serotonin - metabolism
Terminology as Topic
Tissue Distribution
Vertebrates: nervous system and sense organs
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Summary:Though both the amygdala and the serotonin system appear to play critical roles in regulating fear and anxiety, little is known regarding the organization of serotonergic inputs to the primate amygdala. The present study employed immunohistochemistry to determine the distribution of serotonin fibers in the macaque amygdala. The brains of three adult male Macaca fascicularis monkeys were prepared for histological analysis using a polyclonal antibody to serotonin. The macaque amygdala is densely innervated by serotonergic fibers and demonstrates a distinctive pattern of fiber distribution and density among the 13 nuclei and cortical areas. The highest density of 5-hydroxytryptamine immunoreactive fibers is observed in the central nucleus, the nucleus of the lateral olfactory tract, the paralaminar nucleus, the anterior amygdaloid area and a small region of the amygdalohippocampal area. Moderate fiber densities are found in portions of the basal, lateral, and intercalated nuclei. The lowest fiber densities are observed in the accessory basal, posterior cortical, anterior cortical and medial nuclei, and in subregions of the periamygdaloid cortex. The present study provides evidence that the serotonergic system can have substantial influence on the ongoing activity of the amygdaloid complex.
ISSN:0306-4522
1873-7544
DOI:10.1016/j.neuroscience.2005.07.040