Microbial synthesis of hyaluronan and chitin: New approaches

Hyaluronan (HA) is an important structural element in the vitreous humor of the eye, synovial fluid, and skin of vertebrates. Moreover, HA interacts with proteins such as CD44, RHAMM, and fibrinogen, thereby influencing many natural processes such as angiogenesis, cancer, cell motility, wound healin...

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Bibliographic Details
Published in:Journal of bioscience and bioengineering 2005-06, Vol.99 (6), p.521-528
Main Authors: Yamada, Takashi, Kawasaki, Takeru
Format: Article
Language:English
Subjects:
Biological and medical sciences
BIOSYNTHESIS
Biotechnology
CHITIN
Chitin - biosynthesis
Chitin - genetics
Chlorella - genetics
Chlorella - metabolism
Chlorovirus
Fundamental and applied biological sciences. Psychology
Glucuronosyltransferase - genetics
Glucuronosyltransferase - metabolism
hyaluronan
Hyaluronan Synthases
HYALURONIC ACID
Hyaluronic Acid - biosynthesis
Hyaluronic Acid - genetics
metabolic engineering
Protein Engineering - methods
Protein Engineering - trends
Recombinant Proteins - metabolism
Streptococcus - genetics
Streptococcus - metabolism
VERTEBRATES
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Summary:Hyaluronan (HA) is an important structural element in the vitreous humor of the eye, synovial fluid, and skin of vertebrates. Moreover, HA interacts with proteins such as CD44, RHAMM, and fibrinogen, thereby influencing many natural processes such as angiogenesis, cancer, cell motility, wound healing, and cell adhesion. Reflecting such a variety of functions, HA has attracted attention from a wide range of application fields such as medicine (including surgery), cosmetics, and health foods. Traditionally HA was extracted from rooster combs, but nowadays is produced by the fermentation of streptococci. At present, quality issues such as purity and molecular weight distribution, rather than quantity, have been the focus of strain and process development in HA production. To meet ever-increasing public demand, novel systems that can yield sufficient amounts of high-quality of HA and related materials are required.
ISSN:1389-1723
1347-4421
DOI:10.1263/jbb.99.521