Recipient levels and function of von Willebrand factor prior to liver transplantation and its consumption in the course of grafting correlate with hepatocellular damage and outcome

Summary Von Willebrand factor (vWF) is a major platelet adhesion molecule at sites of vascular injury, such as observed in ischemia/reperfusion injury following orthotopic liver transplantation (OLT). Thirty‐three OLT patients were divided into groups with elevated or low markers of hepatocellular d...

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Bibliographic Details
Published in:Transplant international 2005-11, Vol.18 (11), p.1258-1265
Main Authors: Esch, Jan Schulte am, Tustas, Roy Y., Robson, Simon C., Hosch, Stefan B., Akyildiz, Ayse, Bröring, Dieter C., Fischer, Lutz, Knoefel, Wolfram T., Rogiers, Xavier
Format: Article
Language:English
Subjects:
Adult
Alanine Transaminase - blood
Biological and medical sciences
Biomarkers - blood
Blood Coagulation
coagulation
General aspects
Graft Survival
Humans
ischemia/reperfusion injury
Liver - pathology
Liver - surgery
Liver Function Tests
Liver Transplantation
Medical sciences
Middle Aged
Nephrology. Urinary tract diseases
orthotopic liver transplantation
Pharmacology. Drug treatments
Platelet Aggregation
Platelet Count
Reperfusion Injury - blood
Reperfusion Injury - pathology
von Willebrand factor
von Willebrand Factor - metabolism
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Summary:Summary Von Willebrand factor (vWF) is a major platelet adhesion molecule at sites of vascular injury, such as observed in ischemia/reperfusion injury following orthotopic liver transplantation (OLT). Thirty‐three OLT patients were divided into groups with elevated or low markers of hepatocellular damage (high and low‐HD). Whole‐blood aggregometry was performed to evaluate platelet function. Multimeric analysis was utilized to evaluate functional vWF levels in the course of OLT. Donor and recipient demographics were comparable among groups. Low‐HD patients demonstrated better preserved coagulation parameters on POD 1–6 if contrasted to high‐HD patients. One year graft survival for the high‐HD group was lower than low‐HD patients (P = 0.037). Preoperative vWF‐dependent platelet aggregation and functional vWF plasma levels correlated directly with alanine transaminase levels early after OLT as did the decrease of functional vWF to reperfusion. In summary, these data suggest that vWF may serve as a significant mediator of platelet recruitment and hepatocellular injury in the graft following reperfusion.
ISSN:0934-0874
1432-2277
DOI:10.1111/j.1432-2277.2005.00110.x