Evaluation of a structural polymorphism in the ankyrin repeat and kinase domain containing 1 (ANKK1) gene and the activation of executive attention networks

The specificity of genetic effects on brain activation is a central issue in understanding how molecular actions at the synapse relate to anatomic patterns of brain activity. In an effort to understand the basis for the specificity of gene-associated brain activity, we explore a well-studied genetic...

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Bibliographic Details
Published in:Cognitive, affective, & behavioral neuroscience affective, & behavioral neuroscience, 2006-03, Vol.6 (1), p.71-78
Main Authors: FOSSELLA, John, GREEN, Adam E, JIN FAN
Format: Article
Language:English
Subjects:
Adolescent
Adult
Alleles
Analysis of Variance
Anatomical correlates of behavior
Attention - physiology
Behavioral psychophysiology
Biological and medical sciences
Brain
Chromosome Mapping
DNA Mutational Analysis - methods
Dopamine
Female
Fundamental and applied biological sciences. Psychology
Gene expression
Gene Frequency
Gyrus Cinguli - blood supply
Gyrus Cinguli - physiology
Humans
Image Processing, Computer-Assisted - methods
Kinases
Linkage Disequilibrium
Magnetic Resonance Imaging - methods
Male
Neural networks
Neuropsychological Tests - statistics & numerical data
Oxygen - blood
Polymorphism
Polymorphism, Genetic
Problem Solving - physiology
Protein-Serine-Threonine Kinases - genetics
Psychology. Psychoanalysis. Psychiatry
Psychology. Psychophysiology
Reaction Time - genetics
Receptors, Dopamine D2 - genetics
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Summary:The specificity of genetic effects on brain activation is a central issue in understanding how molecular actions at the synapse relate to anatomic patterns of brain activity. In an effort to understand the basis for the specificity of gene-associated brain activity, we explore a well-studied genetic polymorphism, TaqIA, which lies downstream of the DRD2 gene in the protein-encoding region of a neighboring gene, ANKK1, which is not expressed in the brain. We utilize the attention network test and find that carriers of the A1 allele show gene-associated functional activation in an anatomically specific, dopamine-rich region of the brain comprising the anterior cingulate gyrus, a finding partially consistent with prior data from functional imaging genetics. A review of the patterns of expression for ANKK1 and DRD2 and the extent of linkage disequilibrium between the two genes sheds light on additional criteria for the selection of candidate genes in imaging-genetic studies.
ISSN:1530-7026
1531-135X
DOI:10.3758/CABN.6.1.71