Idiopathic recurrent acute pericarditis: familial Mediterranean fever mutations and disease evolution in a large cohort of Caucasian patients

Idiopathic recurrent acute pericarditis (IRAP) is suspected to be an autoimmune phenomenon. We studied 46 consecutive patients. We looked for: 1) the occurrence of new diagnoses of autoimmune diseases during our follow up; 2) HLA typing; and 3) the presence of the most frequent mutations linked to f...

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Bibliographic Details
Published in:Lupus 2005-01, Vol.14 (9), p.670-674
Main Authors: Brucato, A, Shinar, Y, Brambilla, G, Robbiolo, L, Ferrioli, G, Patrosso, M C, Zanni, D, Penco, S, Boiani, E, Ghirardello, A, Caforio, A LP, Bergantin, A, Tombini, V, Moreo, A, Ashtamkar, L, Doria, A, Shoenfeld, Y, Livneh, A
Format: Article
Language:English
Subjects:
Arthritis, Rheumatoid - diagnosis
Arthritis, Rheumatoid - genetics
Arthritis, Rheumatoid - immunology
Autoimmune diseases
Autoimmune Diseases - genetics
Biological Evolution
Cardiology
Disease
DNA Mutational Analysis
Familial Mediterranean Fever - complications
Familial Mediterranean Fever - diagnosis
Familial Mediterranean Fever - genetics
Familial Mediterranean Fever - immunology
Female
Fever
Genetic Predisposition to Disease
Genotype
HLA Antigens - genetics
Hospitals
Humans
Italy
Lupus
Male
Mutation
Pathogenesis
Patients
Pericarditis
Pericarditis - etiology
Pericarditis - genetics
Pericarditis - immunology
Serology
Sjogren's Syndrome - diagnosis
Sjogren's Syndrome - genetics
Sjogren's Syndrome - immunology
White people
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Summary:Idiopathic recurrent acute pericarditis (IRAP) is suspected to be an autoimmune phenomenon. We studied 46 consecutive patients. We looked for: 1) the occurrence of new diagnoses of autoimmune diseases during our follow up; 2) HLA typing; and 3) the presence of the most frequent mutations linked to familial Mediterranean fever (FMF gene or MEFV). HLA typing was done in 21 patients at loci B, DRB1, DQA1 and DQB1. MEFV gene was looked in 23 patients using specific primers. During the follow-up we made a new diagnosis of primary Sjögren’s syndrome in four patients (8.7%) and of rheumatoid arthritis in one patient (2.2%). HLA B14, DRB1*01 and DQB1*0202 were significantly more prevalent, but we did not find a typical HLA typing. MEFV gene was searched: exon 10 was checked by sequence and the E148Q mutation by restriction site analysis. No mutations were found. In conclusion, the prevalence of definite immunorheumatological diseases and the absence of the mutations linked to FMF reinforce the notion that idiopathic acute recurrent pericarditis is an autoimmune condition.
ISSN:0961-2033
1477-0962
DOI:10.1191/0961203305lu2197oa