Complete remission in a pancytopenic HIV negative, HHV-8 positive patient with multicentric Castleman's disease induced with anti-CD20

A 75-year-old woman was diagnosed of MCD plasma cell (PC) variant with B symptoms. Diffuse lymph-node enlargement, splenomegaly and pancytopenia were detected. Induction with Rituximab was made because pancytopenia was present. Actually patient is free of disease. This is the first complete response...

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Bibliographic Details
Published in:Clinical & translational oncology 2006-07, Vol.8 (7), p.540-541
Main Authors: Cervera Grau, J M, Galiana Esquerdo, G, Llorca Ferrándiz, C, Briceño García, H, Díaz Castellano, M, Férriz Moreno, P
Format: Article
Language:English
Subjects:
Aged
Antibodies, Monoclonal - therapeutic use
Antibodies, Monoclonal, Murine-Derived
Antigens, CD20
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
Castleman Disease - complications
Castleman Disease - drug therapy
Castleman Disease - immunology
Female
Herpesviridae Infections - complications
Herpesvirus 8, Human
HIV Seronegativity
Humans
Pancytopenia - complications
Remission Induction
Rituximab
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Summary:A 75-year-old woman was diagnosed of MCD plasma cell (PC) variant with B symptoms. Diffuse lymph-node enlargement, splenomegaly and pancytopenia were detected. Induction with Rituximab was made because pancytopenia was present. Actually patient is free of disease. This is the first complete response of MCD published, VIH negative, induced with anti CD20.
ISSN:1699-048X
1699-3055
DOI:10.1007/s12094-006-0056-2