MEMORY IMPROVEMENT WITH TREATMENT OF HYPOTHYROIDISM

The consequences of inadequate thyroid hormone availability to the brain and treatment effects of levothyroxine on cognitive function are still poorly understood. This study prospectively assessed the effects of thyroid replacement therapy on cognitive function in patients suffering from biochemical...

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Bibliographic Details
Published in:International journal of neuroscience 2006-08, Vol.116 (8), p.895-906
Main Authors: MILLER, KAREN J., PARSONS, THOMAS D., WHYBROW, PETER C., HERLE, KATJA VAN, RASGON, NATALIE, HERLE, ANDRE VAN, MARTINEZ, DOROTHY, SILVERMAN, DAN H., BAUER, MICHAEL
Format: Article
Language:English
Subjects:
Adolescent
Adult
Analysis of Variance
Behavioral psychophysiology
Biological and medical sciences
cognition
Endocrinopathies
Female
Follow-Up Studies
Fundamental and applied biological sciences. Psychology
Humans
hypothyroidism
Hypothyroidism - complications
Hypothyroidism - drug therapy
levothyroxine
Male
Medical sciences
memory
Memory Disorders - drug therapy
Memory Disorders - etiology
Mental Status Schedule
Middle Aged
neuropsychological tests
Neuropsychological Tests - statistics & numerical data
Non tumoral diseases. Target tissue resistance. Benign neoplasms
Prospective Studies
Psychology. Psychoanalysis. Psychiatry
Psychology. Psychophysiology
Thyroid. Thyroid axis (diseases)
Thyroxine - therapeutic use
Verbal Learning - drug effects
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Summary:The consequences of inadequate thyroid hormone availability to the brain and treatment effects of levothyroxine on cognitive function are still poorly understood. This study prospectively assessed the effects of thyroid replacement therapy on cognitive function in patients suffering from biochemical evidenced, untreated hypothyroidism. Significant effects between the untreated hypothyroid group and control group were limited to verbal memory retrieval. When assessing the effects of 3-month treatment, results revealed that the treated hypothyroid group had significant increased verbal memory retrieval. Results suggest that specific memory retrieval deficits associated with hypothyroidism can resolve after replacement therapy with levothyroxine.
ISSN:0020-7454
1563-5279
1543-5245
DOI:10.1080/00207450600550154