Genetic polymorphisms in autochthonous Basques from Northern Navarre

This survey reports primary results of classical allele frequencies on ten protein loci in a Basque population sample from northern Navarre, the less known from an anthropological and genetic point of view than the populations of the other Basque territories of Spain. Since ancient times this has be...

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Bibliographic Details
Published in:Anthropologischer Anzeiger 2006-06, Vol.64 (2), p.173-187
Main Authors: Calderón, Rosario, Pérez-Miranda, Ana M., Fuciarelli, Maria, Scano, Giusepina, Carrión, Mónica, Alfonso-Sánchez, Miguel A., Peña, José A., Ambrosio, Beatriz, De Stefano, GianFranco
Format: Article
Language:English
Subjects:
Alleles
Animal genetics
Baskenland
Basque territory
Blood Proteins - genetics
Chromosome Mapping
classical allele frequencies
DNA Mutational Analysis
European Continental Ancestry Group - genetics
Evolutionary genetics
Gene frequency
Genetic loci
Genetic Markers - genetics
Genetic variation
Genetic Variation - genetics
Genetics, Population
Geography
Human genetics
Humans
Iberian Peninsula
Iberische Halbinsel
klassische Allelfrequenzen
northern Navarre
nördliches Navarra
Originalarbeiten
Polymorphism, Genetic - genetics
Polymorphism, Single Nucleotide - genetics
population genetic structure
Population genetics
Population Groups - statistics & numerical data
Population structure
populationsgenetische Struktur
protein loci
Proteinloci
Quantitative Trait Loci - genetics
Spain - epidemiology
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Summary:This survey reports primary results of classical allele frequencies on ten protein loci in a Basque population sample from northern Navarre, the less known from an anthropological and genetic point of view than the populations of the other Basque territories of Spain. Since ancient times this has been a zone of Basque population settlement, and the Basque language (Euskera) still remains deeply rooted among its autochthonous population. A total of 122 blood samples from unrelated northern Navarrese with autochthonous ascendants to the third generation were typed for GC, HP, PI, TF, ACP1, AK1, CA2, ESD, PGD and PGM1 genetic systems. Basque surnames and birthplaces were the criteria used to define family origins. Genetic structure was analyzed on different population hierarchical levels. Northern Navarre seems to be the most genetically deviated area in comparison with other Basque groups. The highest level of differentiation is observed between Navarrese and Alava Basques whereas Guipúzcoa province, the territory adjacent to northern Navarre, presents the lowest genetic distance from the study area. Northern Navarrese show some distinguishing genetic characteristics in relation to other Basque relative samples, which include high frequencies for PI*M1 and TF*C1 and low levels of PGD*C and PGM1*2 alleles. When the genetic data reported here are analyzed jointly with GM allotypes frequencies, the results significantly reinforce the relative position of Navarrese Basques as well as the topology of the Basque cluster on genetic maps. The analysis of relationships among the genetic structures of Basque population samples leads us to ask ourselves which of them fits in best with the ancient Basque population. Classical geographers placed the tribe of the Vascones in the geographical region currently known as Navarre, so extant Navarrese Basques might be considered firm candidates to denote the anthropological and genomic distinctiveness of the ancient Basques. Diese Untersuchung gibt die vorläufigen Ergebnisse bezüglich der klassischen Allelfrequenzen von 10 Proteinloci in einer baskischen Population wieder, die unter anthropologischem und genetischem Aspekt im Vergleich zu den Populationen der anderen baskischen Gebiete Spaniens am wenigsten bekannt ist. Seit alter Zeit ist dies eine Zone baskischer Besiedlung, und die baskische Sprache (Euskera) ist in dieser autochthonen Population tief verwurzelt. Insgesamt wurden 122 Blutproben nichtverwandter nördlicher Nav
ISSN:0003-5548
2363-7099
DOI:10.1127/anthranz/64/2006/173