Serotonin Reciprocally Regulates Melanocortin Neurons to Modulate Food Intake

The neural pathways through which central serotonergic systems regulate food intake and body weight remain to be fully elucidated. We report that serotonin, via action at serotonin1B receptors (5-HT 1BRs), modulates the endogenous release of both agonists and antagonists of the melanocortin receptor...

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Bibliographic Details
Published in:Neuron (Cambridge, Mass.) Mass.), 2006-07, Vol.51 (2), p.239-249
Main Authors: Heisler, Lora K., Jobst, Erin E., Sutton, Gregory M., Zhou, Ligang, Borok, Erzsebet, Thornton-Jones, Zoe, Liu, Hong Yan, Zigman, Jeffrey M., Balthasar, Nina, Kishi, Toshiro, Lee, Charlotte E., Aschkenasi, Carl J., Zhang, Chen-Yu, Yu, Jia, Boss, Olivier, Mountjoy, Kathleen G., Clifton, Peter G., Lowell, Bradford B., Friedman, Jeffrey M., Horvath, Tamas, Butler, Andrew A., Elmquist, Joel K., Cowley, Michael A.
Format: Article
Language:English
Subjects:
Animals
Brain research
Diabetes
Drug dosages
Eating - drug effects
Eating - physiology
Electric Stimulation
Food
Homeostasis
HUMDISEASE
Male
Mice
Mice, Inbred A
Mice, Inbred C57BL
Mice, Knockout
Mice, Obese
Mice, Transgenic
MOLNEURO
Monitoring systems
Nerve Net - drug effects
Nerve Net - physiology
Neurons
Neurons - drug effects
Neurons - physiology
Nutrition research
Obesity
Pyridines - pharmacology
Receptor, Melanocortin, Type 3 - physiology
Receptor, Melanocortin, Type 4 - agonists
Receptor, Melanocortin, Type 4 - antagonists & inhibitors
Receptor, Melanocortin, Type 4 - physiology
Receptor, Serotonin, 5-HT1B - physiology
Receptors, Melanocortin - agonists
Receptors, Melanocortin - antagonists & inhibitors
Receptors, Melanocortin - physiology
Rodents
Serotonin - pharmacology
Serotonin - physiology
Serotonin 5-HT1 Receptor Agonists
Variance analysis
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Summary:The neural pathways through which central serotonergic systems regulate food intake and body weight remain to be fully elucidated. We report that serotonin, via action at serotonin1B receptors (5-HT 1BRs), modulates the endogenous release of both agonists and antagonists of the melanocortin receptors, which are a core component of the central circuitry controlling body weight homeostasis. We also show that serotonin-induced hypophagia requires downstream activation of melanocortin 4, but not melanocortin 3, receptors. These results identify a primary mechanism underlying the serotonergic regulation of energy balance and provide an example of a centrally derived signal that reciprocally regulates melanocortin receptor agonists and antagonists in a similar manner to peripheral adiposity signals.
ISSN:0896-6273
1097-4199
DOI:10.1016/j.neuron.2006.06.004