Signalling mechanisms linking hepatic glucose and lipid metabolism

Fatty liver and hepatic triglyceride accumulation are strongly associated with obesity, insulin resistance and type 2 diabetes, and are subject to nutritional influences. Hepatic regulation of glucose and lipid homeostasis is influenced by a complex system of hormones, hormonally regulated signallin...

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Bibliographic Details
Published in:Diabetologia 2006-08, Vol.49 (8), p.1732-1741
Main Authors: WEICKERT, M. O, PFEIFFER, A. F. H
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Diabetes
Diabetes Mellitus, Type 2 - complications
Diabetes Mellitus, Type 2 - metabolism
Diabetes. Impaired glucose tolerance
DNA-Binding Proteins - physiology
Endocrine pancreas. Apud cells (diseases)
Endocrinopathies
Etiopathogenesis. Screening. Investigations. Target tissue resistance
Fatty acids
Fatty Liver - metabolism
Gastroenterology. Liver. Pancreas. Abdomen
Glucose
Glucose - metabolism
Homeostasis
Humans
Insulin resistance
Kinases
Lipids
Lipids - physiology
Liver
Liver - metabolism
Liver X Receptors
Liver. Biliary tract. Portal circulation. Exocrine pancreas
Medical sciences
Metabolism
Metabolites
Models, Biological
Nutrition
Obesity
Orphan Nuclear Receptors
Other diseases. Semiology
Proteins
Receptors, Cytoplasmic and Nuclear - physiology
Signal Transduction - physiology
Sterol Regulatory Element Binding Proteins - metabolism
Transcription factors
Triglycerides - metabolism
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Summary:Fatty liver and hepatic triglyceride accumulation are strongly associated with obesity, insulin resistance and type 2 diabetes, and are subject to nutritional influences. Hepatic regulation of glucose and lipid homeostasis is influenced by a complex system of hormones, hormonally regulated signalling pathways and transcription factors. Recently, considerable progress has been made in elucidating molecular pathways and potential factors that are affected in insulin-resistant states. In this review we discuss some of the key factors that are involved in both the regulation of glucose and lipid metabolism in the liver. Understanding the molecular network that links hepatic lipid accumulation and impaired glucose metabolism may provide targets for dietary or pharmacological interventions.
ISSN:0012-186X
1432-0428
DOI:10.1007/s00125-006-0295-3