Osseous integration of calcium phosphate in osteoporotic vertebral fractures after kyphoplasty : initial results from a clinical and experimental pilot study

This study evaluated the radiological changes at the bone-cement interface of calcium phosphate cement (CPC) and polymethylmethacrylate (PMMA) 12 months after kyphoplasty. In a pilot experiment, we additionally performed a histomorphometric analysis in osteopenic foxhounds to analyze the process of...

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Bibliographic Details
Published in:Osteoporosis international 2006-08, Vol.17 (8), p.1208-1215
Main Authors: LIBICHER, M, HILLMEIER, J, NAWROTH, P, KASPERK, C, LIEGIBEL, U, SOMMER, U, PYERIN, W, VETTER, M, MEINZER, H.-P, GRAFE, I, MEEDER, P, NÖLDGE, G
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Bone Cements - metabolism
Bones
Calcium phosphates
Calcium Phosphates - metabolism
Diseases of the osteoarticular system
Dogs
Female
Fractures
Fractures, Compression - surgery
Humans
Injuries of the limb. Injuries of the spine
Medical sciences
Osseointegration
Osteoporosis
Osteoporosis - pathology
Osteoporosis - surgery
Osteoporosis. Osteomalacia. Paget disease
Pilot Projects
Polymethyl Methacrylate
Spinal Fractures - pathology
Spinal Fractures - surgery
Tomography
Tomography, X-Ray Computed
Transplants & implants
Traumas. Diseases due to physical agents
Vertebrae
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Summary:This study evaluated the radiological changes at the bone-cement interface of calcium phosphate cement (CPC) and polymethylmethacrylate (PMMA) 12 months after kyphoplasty. In a pilot experiment, we additionally performed a histomorphometric analysis in osteopenic foxhounds to analyze the process of osseous integration of CPC and PMMA. Twenty postmenopausal female patients with 46 vertebral compression fractures (VCF) were treated by kyphoplasty, utilizing CPC (N=28) or PMMA (N=18) for intravertebral stabilization. After a 12-month follow-up, we measured the density changes of border voxels at the bone-cement interface by computed tomography (CT) using dedicated software algorithms. We defined the border-voxel density (BVD) as a parameter of cement resorption at the interface. We also investigated the bone-implant interface in three osteopenic foxhounds by histomorphometry 3, 6, and 12 months after cement implantation. Twelve months after kyphoplasty, only CPC showed a significant decrease of the BVD compared to PMMA (p
ISSN:0937-941X
1433-2965
DOI:10.1007/s00198-006-0128-8