Cyclooxygenase-2 expression in Warthin's tumour

Objectives: To determine whether cyclooxygenase-2 (COX-2) is overexpressed in Warthin's tumours, and to characterize its pattern of expression. Methods: Twenty-one paraffin-embedded Warthin's tumour specimens were analysed by immunohistochemical staining for expression of human COX-2. Semi...

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Bibliographic Details
Published in:Journal of laryngology and otology 2005-07, Vol.119 (7), p.515-518
Main Authors: Loy, A H C, Putti, T C, Tan, L K S
Format: Article
Language:English
Subjects:
(RF) Otorhinolaryngology
Adenolymphoma - enzymology
Adult
Aged
Aged, 80 and over
Antibodies
Biological and medical sciences
Cancer
Cyclooxygenase 2 - analysis
Cyclooxygenase-2
Enzymes
Epithelium - enzymology
Exocrine glands
Facial bones, jaws, teeth, parodontium: diseases, semeiology
Humans
Hypotheses
Immunohistochemistry
Immunohistochemistry - methods
Lymphatic system
Lymphoid Tissue - enzymology
Male
Medical sciences
Middle Aged
Otorhinolaryngology. Stomatology
Parotid Gland - enzymology
Pathogenesis
Salivary Ducts - enzymology
Tumors
Warthin’s Tumour
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Summary:Objectives: To determine whether cyclooxygenase-2 (COX-2) is overexpressed in Warthin's tumours, and to characterize its pattern of expression. Methods: Twenty-one paraffin-embedded Warthin's tumour specimens were analysed by immunohistochemical staining for expression of human COX-2. Semi-quantitative analysis of the staining was performed. Results: In all of the specimens, we found that there was overexpression of COX-2 within the epithelial component of the tumours, with no expression in the lymphoid components. There was also overexpression of COX-2 in the salivary duct system of normal parotid tissue. Conclusions: Our results suggest that COX-2 is up-regulated in the epithelial component of Warthin's tumours. Our findings support the hypothesis that Warthin's tumours originate from heterotopic ductal epithelial cells of the parotid gland. The role of COX-2 expression in the pathogenesis of Warthin's tumours remains to be determined.
ISSN:0022-2151
1748-5460
DOI:10.1258/0022215054352117