Proteasomal Oscillation during Mild Heat Shock in Aging Human Skin Fibroblasts

:  Augmentation of proteasome machinery is emerging as a significant gerontomodulatory consequence of hormetic stimulation, such as mild heat stress. This study describes the phenomenon we term hormetic proteasomal oscillation, wherein mildly heat‐stressed human fibroblasts (41°C, 1 h) display an ad...

Full description

Saved in:
Bibliographic Details
Published in:Annals of the New York Academy of Sciences 2006-05, Vol.1067 (1), p.224-227
Main Authors: KRAFT, DAVID CHRISTIAN, DEOCARIS, CUSTER C., RATTAN, SURESH I. S.
Format: Article
Language:English
Subjects:
Adult
aging
Cells, Cultured
Cellular Senescence - physiology
Female
fibroblast
Fibroblasts - chemistry
Fibroblasts - metabolism
Fibroblasts - physiology
heat stress
Heat-Shock Response - physiology
hormesis
Humans
Nrf2
proteasome
Proteasome Endopeptidase Complex - analysis
Proteasome Endopeptidase Complex - metabolism
Skin Aging
Time Factors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary::  Augmentation of proteasome machinery is emerging as a significant gerontomodulatory consequence of hormetic stimulation, such as mild heat stress. This study describes the phenomenon we term hormetic proteasomal oscillation, wherein mildly heat‐stressed human fibroblasts (41°C, 1 h) display an adaptation response pattern in proteasome activity. Remarkably, such response appears to be diverse in severely heat‐stressed or senescent fibroblasts. This proteasomal oscillation, as an innate cellular reaction to heat and aging, however, is independent of 20S proteasome protein levels and nuclear factor‐E2‐related factor 2 (Nrf2) transactivation.
ISSN:0077-8923
1749-6632
DOI:10.1196/annals.1354.028