Intercellular adhesion molecule-1 (ICAM-1) in ulcerative colitis: presence, visualization, and significance

The intensive research of recent years has suggested that the cause of ulcerative colitis (UC) involves a genetic predisposition to an uncontrolled or unbalanced immune response to luminal or epithelial antigens or against other external factors. Intercellular adhesion molecule-1 (ICAM-1) is pivotal...

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Bibliographic Details
Published in:Inflammation research 2005-08, Vol.54 (8), p.313-327
Main Author: Vainer, B
Format: Article
Language:English
Subjects:
Animals
Antibodies, Monoclonal - chemistry
Colitis, Ulcerative - metabolism
Colon - metabolism
Endothelium, Vascular - metabolism
Endothelium, Vascular - pathology
Gene Expression Regulation
Granulocytes - metabolism
Humans
Intercellular Adhesion Molecule-1 - biosynthesis
Intercellular Adhesion Molecule-1 - physiology
Intestinal Mucosa - pathology
Lymphocytes - metabolism
Microscopy, Electron
Models, Biological
Neutrophils - metabolism
Polymorphism, Genetic
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Summary:The intensive research of recent years has suggested that the cause of ulcerative colitis (UC) involves a genetic predisposition to an uncontrolled or unbalanced immune response to luminal or epithelial antigens or against other external factors. Intercellular adhesion molecule-1 (ICAM-1) is pivotal for the influx of neutrophil granulocytes into colonic mucosa, and gene analyses have found polymorphisms in the gene encoding ICAM-1, indicating that changes in ICAM-1 function may be involved in the pathogenesis of UC. Clinical trials of the ICAM-1 antisense oligonucleotide Alicaforsen, which inhibits the synthesis of ICAM-1, have shown positive results in the treatment of patients with left-sided (distal) UC. In addition to emphasizing the central role of ICAM-1 in active stages of UC, the results provide hope for the development and introduction of a more specific and efficient treatment for UC than those currently available. This review discusses the results from studies on the expression of ICAM-1 in colonic tissue from patients with UC.
ISSN:1023-3830
1420-908X
DOI:10.1007/s00011-005-1363-8