Gene profiling changes in cytoskeletal proteins during clinical recovery after left ventricular-assist device support

After left ventricular-assist device (LVAD) support, a proportion of patients recover sufficient ventricular function to enable explantation of the device. The exact molecular mechanisms involved in myocardial recovery remain unknown. Cytoskeletal proteins are essential for the structure and functio...

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Bibliographic Details
Published in:Circulation (New York, N.Y.) N.Y.), 2005-08, Vol.112 (9), p.I57-I64
Main Authors: BIRKS, Emma J, HALL, Jennifer L, YACOUB, Magdi H, BARTON, Paul J. R, GRINDLE, Suzanne, LATIF, Najma, HARDY, James P, RIDER, James E, BANNER, Nicholas R, KHAGHANI, Asghar, MILLER, Leslie W
Format: Article
Language:English
Subjects:
Adrenergic beta-2 Receptor Agonists
Adrenergic beta-Agonists - therapeutic use
Adult
Alcoholism and acute alcohol poisoning
Associated diseases and complications
Biological and medical sciences
Blood and lymphatic vessels
Cardiology. Vascular system
Cardiomyopathies - complications
Cardiomyopathies - drug therapy
Cardiomyopathies - genetics
Cardiomyopathies - metabolism
Cardiomyopathies - surgery
Cardiovascular Agents - therapeutic use
Clenbuterol - therapeutic use
Combined Modality Therapy
Convalescence
Cytoskeletal Proteins - biosynthesis
Cytoskeletal Proteins - genetics
Device Removal
Diabetes. Impaired glucose tolerance
Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous
Endocrine pancreas. Apud cells (diseases)
Endocrinopathies
Female
Gene Expression Profiling
Heart Failure - drug therapy
Heart Failure - etiology
Heart Failure - genetics
Heart Failure - surgery
Heart-Assist Devices
Hemodynamics
Humans
Integrins - biosynthesis
Integrins - genetics
Male
Medical sciences
Middle Aged
Myocytes, Cardiac - metabolism
Oligonucleotide Array Sequence Analysis
Postoperative Period
Reverse Transcriptase Polymerase Chain Reaction
Toxicology
Treatment Outcome
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Description
Summary:After left ventricular-assist device (LVAD) support, a proportion of patients recover sufficient ventricular function to enable explantation of the device. The exact molecular mechanisms involved in myocardial recovery remain unknown. Cytoskeletal proteins are essential for the structure and function of the cardiac myocyte and might play a major role. A total of 15 patients with nonischemic cardiomyopathy who required LVAD implantation were studied; 6 recovered sufficiently to allow explantation of the device compared with 9 who did not recover and required transplantation. LV myocardial samples were collected at implantation and explantation/transplantation. Affymetrix microarray analysis was performed on the paired samples and analyzed with reference to sarcomeric and nonsarcomeric cytoskeletal proteins. In the recovery group, of the nonsarcomeric proteins, lamin A/C increased 1.5-fold (P
ISSN:0009-7322
1524-4539
DOI:10.1161/CIRCULATIONAHA.104.526137