IGF-I and epidermal growth factor levels in follicular fluid of women undergoing controlled ovarian hyperstimulation using the multidose GnRH-antagonist protocol or the long GnRH-agonist protocol

The intrafollicular levels of IGF-I and epidermal growth factor (EGF) were studied in women undergoing controlled ovarian hyperstimulation using the multidose GnRH-antagonist protocol or the long agonist protocol, in an attempt to elucidate whether GnRH-antagonists affect the levels of the two growt...

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Bibliographic Details
Published in:Journal of endocrinological investigation 2006-05, Vol.29 (5), p.RC5-RC8
Main Authors: Asimakopoulos, B, Schöpper, B, Dawson, A, Caglar, G S, Vakalopoulos, I, Al-Hasani, S, Diedrich, K, Nikolettos, N
Format: Article
Language:English
Subjects:
Adult
Epidermal Growth Factor - analysis
Estradiol - analysis
Female
Follicle Stimulating Hormone - therapeutic use
Follicular Fluid - chemistry
Gonadotropin-Releasing Hormone - agonists
Gonadotropin-Releasing Hormone - analogs & derivatives
Gonadotropin-Releasing Hormone - antagonists & inhibitors
Gonadotropin-Releasing Hormone - therapeutic use
Humans
Insulin-Like Growth Factor I - analysis
Menotropins - therapeutic use
Ovulation Induction - methods
Progesterone - analysis
Sperm Injections, Intracytoplasmic
Treatment Outcome
Triptorelin Pamoate - therapeutic use
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Summary:The intrafollicular levels of IGF-I and epidermal growth factor (EGF) were studied in women undergoing controlled ovarian hyperstimulation using the multidose GnRH-antagonist protocol or the long agonist protocol, in an attempt to elucidate whether GnRH-antagonists affect the levels of the two growth factors. The follicular fluid concentration of IGF-I, EGF, estradiol and progesterone were detected in 68 women undergoing ovarian hyperstimulation for intracytoplasmic sperm injection (ICSI) cycles. There were no differences in intrafollicular concentrations of EGF and IGF-I in the two studied groups. Additionally, we found no correlation between the intrafollicular levels of IGF-I or EGF and the ICSI outcome. The intrafollicular levels of IGF-I were positively correlated with those of progesterone. In conclusion, the intrafollicular levels of IGF-I and EGF do not seem to be influenced by the stimulation protocol. The intrafollicular levels of both growth factors can not serve as prognostic markers for the ICSI outcome.
ISSN:0391-4097
1720-8386
DOI:10.1007/bf03344118