Platelet vesicular monoamine transporter density in untreated patients diagnosed with social phobia

The vesicular monoamine transporter (VMAT2) is important in the storage and release of monoamines. Platelet VMAT2 was characterized using high-affinity [ 3H]dihydrotetrabenazine ([ 3H]TBZOH) binding in untreated social phobia (SP) patients ( n = 20) compared with sex- and age-matched healthy control...

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Bibliographic Details
Published in:Psychiatry research 2005-09, Vol.136 (2), p.247-250
Main Authors: Laufer, Neil, Zucker, Michal, Hermesh, Haggai, Marom, Sofi, Gilad, Royi, Nir, Vered, Weizman, Abraham, Rehavi, Moshe
Format: Article
Language:English
Subjects:
[ 3H]dihydrotetrabenazine
Adult
Adult and adolescent clinical studies
Anxiety disorders. Neuroses
Biological and medical sciences
Blood Platelets - cytology
Blood Platelets - metabolism
Cell Count
Female
Humans
Male
Medical sciences
Phobia
Phobic Disorders - diagnosis
Phobic Disorders - metabolism
Platelet
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Social phobia
Surveys and Questionnaires
Tetrabenazine - analogs & derivatives
Tetrabenazine - pharmacokinetics
Vesicular Monoamine Transport Proteins - blood
Vesicular Monoamine Transport Proteins - metabolism
Vesicular monoamine transporter
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Summary:The vesicular monoamine transporter (VMAT2) is important in the storage and release of monoamines. Platelet VMAT2 was characterized using high-affinity [ 3H]dihydrotetrabenazine ([ 3H]TBZOH) binding in untreated social phobia (SP) patients ( n = 20) compared with sex- and age-matched healthy controls ( n = 15). No significant differences in VMAT2 density ( B max) and affinity constants ( K d) were observed.
ISSN:0165-1781
1872-7123
DOI:10.1016/j.psychres.2005.05.004