Preventive Effect of Flavangenol on Ischemia/Reperfusion-Induced Acute Renal Failure in Rats

The effects of flavangenol on ischemia/reperfusion-induced acute renal failure (ARF) in rats were examined. Ischemic ARF was induced by occlusion of the left renal artery and vein for 45 min followed by reperfusion, 2 weeks after contralateral nephrectomy. Renal functional parameters such as blood u...

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Bibliographic Details
Published in:Biological & Pharmaceutical Bulletin 2005, Vol.28(9), pp.1655-1657
Main Authors: Ohkita, Mamoru, Nakajima, Atsushi, Ueda, Kyoko, Takaoka, Masanori, Kiso, Yoshinobu, Matsumura, Yasuo
Format: Article
Language:eng ; jpn
Subjects:
Acute Kidney Injury - pathology
Acute Kidney Injury - prevention & control
acute renal failure
Animals
Biflavonoids - pharmacology
Biflavonoids - therapeutic use
flavangenol
ischemia
Kidney - pathology
Kidney Function Tests
Male
Necrosis
Proanthocyanidins - pharmacology
Proanthocyanidins - therapeutic use
Rats
Rats, Sprague-Dawley
Renal Circulation - physiology
reperfusion
Reperfusion Injury - pathology
Reperfusion Injury - prevention & control
Water-Electrolyte Balance - drug effects
Water-Electrolyte Balance - physiology
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Summary:The effects of flavangenol on ischemia/reperfusion-induced acute renal failure (ARF) in rats were examined. Ischemic ARF was induced by occlusion of the left renal artery and vein for 45 min followed by reperfusion, 2 weeks after contralateral nephrectomy. Renal functional parameters such as blood urea nitrogen, plasma creatinine, creatinine clearance, urine flow, urinary osmolality and fractional excretion of sodium were measured. Renal function in ARF rats markedly decreased at 1 d after reperfusion. Pre-ischemic treatment with flavangenol (3—30 mg/kg, i.v.) attenuated the ischemia/reperfusion-induced renal dysfunction. Histopathological examination of the kidney of ARF rats revealed severe renal damage, such as tubular necrosis and proteinaceous casts in tubuli, which were also significantly suppressed by the administration of flavangenol. These findings suggest that flavangenol supplementation may be a promising candidate for treatments to improve the ischemia/reperfusion-induced renal injury.
ISSN:0918-6158
1347-5215
DOI:10.1248/bpb.28.1655