Polymorphism of Fc gamma RIIa may affect the efficacy of gamma-globulin therapy in Kawasaki disease

We evaluated whether there is a possible relationship between the effectiveness of gamma-globulin treatment for patients with Kawasaki disease (KD) and the polymorphism of Fcgamma RIIa, IIIb, and IIIa. Genomic DNA was extracted from whole blood collected from 56 patients with KD who received gamma-g...

Full description

Saved in:
Bibliographic Details
Published in:Journal of clinical immunology 2005-07, Vol.25 (4), p.309-313
Main Authors: Taniuchi, Shoichiro, Masuda, Midori, Teraguchi, Masayuki, Ikemoto, Yumiko, Komiyama, Yutaka, Takahashi, Hakuo, Kino, Minoru, Kobayashi, Yohnosuke
Format: Article
Language:English
Subjects:
Antigens, CD - genetics
Antigens, CD - physiology
Child
Child, Preschool
Female
gamma-Globulins - therapeutic use
Genotype
GPI-Linked Proteins
Humans
Immunization, Passive
Infant
Injections, Intravenous
Male
Mucocutaneous Lymph Node Syndrome - genetics
Mucocutaneous Lymph Node Syndrome - immunology
Mucocutaneous Lymph Node Syndrome - therapy
Polymorphism, Genetic - immunology
Receptors, IgG - genetics
Receptors, IgG - physiology
Retrospective Studies
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:We evaluated whether there is a possible relationship between the effectiveness of gamma-globulin treatment for patients with Kawasaki disease (KD) and the polymorphism of Fcgamma RIIa, IIIb, and IIIa. Genomic DNA was extracted from whole blood collected from 56 patients with KD who received gamma-globulin treatment. The genotypes for Fcgamma RIIIb-NA(1, 2), Fcgamma RIIa-H/R131, and FcgammaRIIIa-F/V158 were determined to investigate the association between these polymorphisms and the development of coronary lesions (CALs). Twenty-three percent of patients with the HH allele for the Fcgamma RIIa polymorphism progressed to CALs, compared with 60% with the HR and RR alleles. HR and RR alleles may be a predictor of the progression of CALs in KD before the initiation of gamma-globulin therapy.
ISSN:0271-9142
1573-2592
DOI:10.1007/s10875-005-4697-7